Polyamine oxidase

Polyamine oxidase

In enzymology, a polyamine oxidase (EC number|1.5.3.11) is an enzyme that catalyzes the chemical reaction

:N1-acetylspermine + O2 + H2O ightleftharpoons N1-acetylspermidine + 3-aminopropanal + H2O2

The 3 substrates of this enzyme are N1-acetylspermine, O2, and H2O, whereas its 3 products are N1-acetylspermidine, 3-aminopropanal, and H2O2.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with oxygen as acceptor. The systematic name of this enzyme class is N1-acetylspermidine:oxygen oxidoreductase (deaminating). This enzyme is also called 1-N-acetylspermidine:oxygen oxidoreductase (deaminating). It has 2 cofactors: FAD, and Iron.

tructural studies

As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1B37, PDB link|1H81, PDB link|1H82, PDB link|1H83, PDB link|1H84, PDB link|1H86, PDB link|1RSG, PDB link|1YY5, and PDB link|1Z6L.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|294646-71-2."

Gene Ontology (GO) codes


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