GDI1

GDP dissociation inhibitor 1, also known as GDI1, is a human gene.

PBB_Summary
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summary_text = GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI1 is expressed primarily in neural and sensory tissues. Mutations in GDI1 have been linked to X-linked nonspecific mental retardation.cite web | title = Entrez Gene: GDI1 GDP dissociation inhibitor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2664| accessdate = ]

Rab GTPases cycles between the cytosolic compartment, where it is bound to a protein called GDI (GDP Dissociation Inhibitor), and the membrane, where it interacts with a receptor, a nucleotide exchange factor, a GAP (GTPase Activating Protein) and probably other factors that link it to the appropriate SNARE. GDI is non-specific with respect to the rab it binds. However, the exchanger, receptor and GAP, are rab specific.

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Calinisan V, Gravem D, Chen RP, "et al." |title=New insights into potential functions for the protein 4.1 superfamily of proteins in kidney epithelium. |journal=Front. Biosci. |volume=11 |issue= |pages= 1646–66 |year= 2006 |pmid= 16368544 |doi=
*cite journal | author=Rasmussen HH, van Damme J, Puype M, "et al." |title=Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. |journal=Electrophoresis |volume=13 |issue= 12 |pages= 960–9 |year= 1993 |pmid= 1286667 |doi=
*cite journal | author=Matsui Y, Kikuchi A, Araki S, "et al." |title=Molecular cloning and characterization of a novel type of regulatory protein (GDI) for smg p25A, a ras p21-like GTP-binding protein. |journal=Mol. Cell. Biol. |volume=10 |issue= 8 |pages= 4116–22 |year= 1990 |pmid= 2115118 |doi=
*cite journal | author=Shisheva A, Südhof TC, Czech MP |title=Cloning, characterization, and expression of a novel GDP dissociation inhibitor isoform from skeletal muscle. |journal=Mol. Cell. Biol. |volume=14 |issue= 5 |pages= 3459–68 |year= 1994 |pmid= 7513052 |doi=
*cite journal | author=Bächner D, Sedlacek Z, Korn B, "et al." |title=Expression patterns of two human genes coding for different rab GDP-dissociation inhibitors (GDIs), extremely conserved proteins involved in cellular transport. |journal=Hum. Mol. Genet. |volume=4 |issue= 4 |pages= 701–8 |year= 1995 |pmid= 7543319 |doi=
*cite journal | author=Nishimura N, Goji J, Nakamura H, "et al." |title=Cloning of a brain-type isoform of human Rab GDI and its expression in human neuroblastoma cell lines and tumor specimens. |journal=Cancer Res. |volume=55 |issue= 22 |pages= 5445–50 |year= 1995 |pmid= 7585614 |doi=
*cite journal | author=Shapiro AD, Pfeffer SR |title=Quantitative analysis of the interactions between prenyl Rab9, GDP dissociation inhibitor-alpha, and guanine nucleotides. |journal=J. Biol. Chem. |volume=270 |issue= 19 |pages= 11085–90 |year= 1995 |pmid= 7744738 |doi=
*cite journal | author=Sedlacek Z, Konecki DS, Korn B, "et al." |title=Evolutionary conservation and genomic organization of XAP-4, an Xq28 located gene coding for a human rab GDP-dissociation inhibitor (GDI). |journal=Mamm. Genome |volume=5 |issue= 10 |pages= 633–9 |year= 1995 |pmid= 7849400 |doi=
*cite journal | author=Beranger F, Cadwallader K, Porfiri E, "et al." |title=Determination of structural requirements for the interaction of Rab6 with RabGDI and Rab geranylgeranyltransferase. |journal=J. Biol. Chem. |volume=269 |issue= 18 |pages= 13637–43 |year= 1994 |pmid= 8175798 |doi=
*cite journal | author=Sedlacek Z, Korn B, Konecki DS, "et al." |title=Construction of a transcription map of a 300 kb region around the human G6PD locus by direct cDNA selection. |journal=Hum. Mol. Genet. |volume=2 |issue= 11 |pages= 1865–9 |year= 1994 |pmid= 8281148 |doi=
*cite journal | author=Hancock JF, Hall A |title=A novel role for RhoGDI as an inhibitor of GAP proteins. |journal=EMBO J. |volume=12 |issue= 5 |pages= 1915–21 |year= 1993 |pmid= 8491184 |doi=
*cite journal | author=Chen EY, Zollo M, Mazzarella R, "et al." |title=Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci. |journal=Hum. Mol. Genet. |volume=5 |issue= 5 |pages= 659–68 |year= 1997 |pmid= 8733135 |doi=
*cite journal | author=Hamel BC, Kremer H, Wesby-van Swaay E, "et al." |title=A gene for nonspecific X-linked mental retardation (MRX41) is located in the distal segment of Xq28. |journal=Am. J. Med. Genet. |volume=64 |issue= 1 |pages= 131–3 |year= 1996 |pmid= 8826463 |doi= 10.1002/(SICI)1096-8628(19960712)64:1<131::AID-AJMG22>3.0.CO;2-N |doilabel=10.1002/(SICI)1096-8628(19960712)64:1131::AID-AJMG223.0.CO;2-N
*cite journal | author=Wilson AL, Sheridan KM, Erdman RA, Maltese WA |title=Prenylation of a Rab1B mutant with altered GTPase activity is impaired in cell-free systems but not in intact mammalian cells. |journal=Biochem. J. |volume=318 ( Pt 3) |issue= |pages= 1007–14 |year= 1996 |pmid= 8836150 |doi=
*cite journal | author=des Portes V, Billuart P, Carrié A, "et al." |title=A gene for dominant nonspecific X-linked mental retardation is located in Xq28. |journal=Am. J. Hum. Genet. |volume=60 |issue= 4 |pages= 903–9 |year= 1997 |pmid= 9106537 |doi=
*cite journal | author=Gorvel JP, Chang TC, Boretto J, "et al." |title=Differential properties of D4/LyGDI versus RhoGDI: phosphorylation and rho GTPase selectivity. |journal=FEBS Lett. |volume=422 |issue= 2 |pages= 269–73 |year= 1998 |pmid= 9490022 |doi=
*cite journal | author=D'Adamo P, Menegon A, Lo Nigro C, "et al." |title=Mutations in GDI1 are responsible for X-linked non-specific mental retardation. |journal=Nat. Genet. |volume=19 |issue= 2 |pages= 134–9 |year= 1998 |pmid= 9620768 |doi= 10.1038/487
*cite journal | author=Bienvenu T, des Portes V, Saint Martin A, "et al." |title=Non-specific X-linked semidominant mental retardation by mutations in a Rab GDP-dissociation inhibitor. |journal=Hum. Mol. Genet. |volume=7 |issue= 8 |pages= 1311–5 |year= 1998 |pmid= 9668174 |doi=
*cite journal | author=Wan M, Francke U |title=Evaluation of two X chromosomal candidate genes for Rett syndrome: glutamate dehydrogenase-2 (GLUD2) and rab GDP-dissociation inhibitor (GDI1). |journal=Am. J. Med. Genet. |volume=78 |issue= 2 |pages= 169–72 |year= 1998 |pmid= 9674910 |doi=
*cite journal | author=Hutt DM, Da-Silva LF, Chang LH, "et al." |title=PRA1 inhibits the extraction of membrane-bound rab GTPase by GDI1. |journal=J. Biol. Chem. |volume=275 |issue= 24 |pages= 18511–9 |year= 2000 |pmid= 10751420 |doi= 10.1074/jbc.M909309199

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