- Cyanocobalamin reductase (cyanide-eliminating)
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Cyanocobalamin reductase (cyanide-eliminating) Identifiers EC number 1.16.1.6 CAS number 131145-00-1 Databases IntEnz IntEnz view BRENDA BRENDA entry ExPASy NiceZyme view KEGG KEGG entry MetaCyc metabolic pathway PRIAM profile PDB structures RCSB PDB PDBe PDBsum Search PMC articles PubMed articles In enzymology, a cyanocobalamin reductase (cyanide-eliminating) (EC 1.16.1.6) is an enzyme that catalyzes the chemical reaction
- cob(I)alamin + cyanide + NADP+ cyanocob(III)alamin + NADPH + H+
The 3 substrates of this enzyme are cob(I)alamin, cyanide, and NADP+, whereas its 3 products are cyanocob(III)alamin, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those oxidizing metal ion with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is cob(I)alamin, cyanide:NADP+ oxidoreductase. Other names in common use include cyanocobalamin reductase, cyanocobalamin reductase (NADPH, cyanide-eliminating), cyanocobalamin reductase (NADPH, CN-eliminating), and NADPH:cyanocob(III)alamin oxidoreductase (cyanide-eliminating). This enzyme participates in porphyrin and chlorophyll metabolism. It employs one cofactor, FAD.
References
- Watanabe F, Oki Y, Nakano Y, Kitaoka S (Tokyo). "Occurrence and characterization of cyanocobalamin reductase (NADPH CN-eliminating) involved in decyanation of cyanocobalamin in Euglena gracilis". J. Nutr. Sci. Vitaminol. (1): 1–10. PMID 3134526.
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