- APOC2
Apolipoprotein C-II, also known as APOC2, is a human
gene .PBB_Summary
section_title =
summary_text = The protein encoded by this gene is secreted in plasma where it is a component ofvery low density lipoprotein . This protein activates the enzymelipoprotein lipase , which hydrolyzes triglycerides and thus provides freefatty acid s for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized byhypertriglyceridemia ,xanthoma s, and increased risk ofpancreatitis and earlyatherosclerosis .cite web | title = Entrez Gene: APOC2 apolipoprotein C-II| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=344| accessdate = ]References
PBB_Further_reading
citations =
*cite journal | author=Jackson RL, Baker HN, Gilliam EB, Gotto AM |title=Primary structure of very low density apolipoprotein C-II of human plasma. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=74 |issue= 5 |pages= 1942–5 |year= 1977 |pmid= 194244 |doi=
*cite journal | author=Lycksell PO, Ohman A, Bengtsson-Olivecrona G, "et al." |title=Sequence specific 1H-NMR assignments and secondary structure of a carboxy-terminal functional fragment of apolipoprotein CII. |journal=Eur. J. Biochem. |volume=205 |issue= 1 |pages= 223–31 |year= 1992 |pmid= 1555583 |doi=
*cite journal | author=Hegele RA, Connelly PW, Maguire GF, "et al." |title=An apolipoprotein CII mutation, CIILys19----Thr' identified in patients with hyperlipidemia. |journal=Dis. Markers |volume=9 |issue= 2 |pages= 73–80 |year= 1992 |pmid= 1782747 |doi=
*cite journal | author=Crecchio C, Capurso A, Pepe G |title=Identification of the mutation responsible for a case of plasmatic apolipoprotein CII deficiency (Apo CII-Bari). |journal=Biochem. Biophys. Res. Commun. |volume=168 |issue= 3 |pages= 1118–27 |year= 1990 |pmid= 1971748 |doi=
*cite journal | author=Bengtsson-Olivecrona G, Sletten K |title=Primary structure of the bovine analogues to human apolipoproteins CII and CIII. Studies on isoforms and evidence for proteolytic processing. |journal=Eur. J. Biochem. |volume=192 |issue= 2 |pages= 515–21 |year= 1990 |pmid= 2209608 |doi=
*cite journal | author=Wei CF, Tsao YK, Robberson DL, "et al." |title=The structure of the human apolipoprotein C-II gene. Electron microscopic analysis of RNA:DNA hybrids, complete nucleotide sequence, and identification of 5' homologous sequences among apolipoprotein genes. |journal=J. Biol. Chem. |volume=260 |issue= 28 |pages= 15211–21 |year= 1986 |pmid= 2415514 |doi=
*cite journal | author=Fojo SS, Lohse P, Parrott C, "et al." |title=A nonsense mutation in the apolipoprotein C-IIPadova gene in a patient with apolipoprotein C-II deficiency. |journal=J. Clin. Invest. |volume=84 |issue= 4 |pages= 1215–9 |year= 1989 |pmid= 2477392 |doi=
*cite journal | author=Jackson CL, Bruns GA, Breslow JL |title=Isolation of cDNA and genomic clones for apolipoprotein C-II. |journal=Meth. Enzymol. |volume=128 |issue= |pages= 788–800 |year= 1986 |pmid= 3014272 |doi=
*cite journal | author=Fojo SS, Law SW, Brewer HB |title=The human preproapolipoprotein C-II gene. Complete nucleic acid sequence and genomic organization. |journal=FEBS Lett. |volume=213 |issue= 1 |pages= 221–6 |year= 1987 |pmid= 3030808 |doi=
*cite journal | author=Fojo SS, Stalenhoef AF, Marr K, "et al." |title=A deletion mutation in the ApoC-II gene (ApoC-II Nijmegen) of a patient with a deficiency of apolipoprotein C-II. |journal=J. Biol. Chem. |volume=263 |issue= 34 |pages= 17913–6 |year= 1989 |pmid= 3192518 |doi=
*cite journal | author=Fojo SS, Beisiegel U, Beil U, "et al." |title=Donor splice site mutation in the apolipoprotein (Apo) C-II gene (Apo C-IIHamburg) of a patient with Apo C-II deficiency. |journal=J. Clin. Invest. |volume=82 |issue= 5 |pages= 1489–94 |year= 1988 |pmid= 3263393 |doi=
*cite journal | author=Connelly PW, Maguire GF, Hofmann T, Little JA |title=Structure of apolipoprotein C-IIToronto, a nonfunctional human apolipoprotein. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 1 |pages= 270–3 |year= 1987 |pmid= 3467353 |doi=
*cite journal | author=Fairwell T, Hospattankar AV, Brewer HB, Khan SA |title=Human plasma apolipoprotein C-II: total solid-phase synthesis and chemical and biological characterization. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 14 |pages= 4796–800 |year= 1987 |pmid= 3474626 |doi=
*cite journal | author=Fojo SS, Taam L, Fairwell T, "et al." |title=Human preproapolipoprotein C-II. Analysis of major plasma isoforms. |journal=J. Biol. Chem. |volume=261 |issue= 21 |pages= 9591–4 |year= 1986 |pmid= 3525527 |doi=
*cite journal | author=Das HK, Jackson CL, Miller DA, "et al." |title=The human apolipoprotein C-II gene sequence contains a novel chromosome 19-specific minisatellite in its third intron. |journal=J. Biol. Chem. |volume=262 |issue= 10 |pages= 4787–93 |year= 1987 |pmid= 3558370 |doi=
*cite journal | author=Connelly PW, Maguire GF, Little JA |title=Apolipoprotein CIISt. Michael. Familial apolipoprotein CII deficiency associated with premature vascular disease. |journal=J. Clin. Invest. |volume=80 |issue= 6 |pages= 1597–606 |year= 1988 |pmid= 3680515 |doi=
*cite journal | author=Baggio G, Manzato E, Gabelli C, "et al." |title=Apolipoprotein C-II deficiency syndrome. Clinical features, lipoprotein characterization, lipase activity, and correction of hypertriglyceridemia after apolipoprotein C-II administration in two affected patients. |journal=J. Clin. Invest. |volume=77 |issue= 2 |pages= 520–7 |year= 1986 |pmid= 3944267 |doi=
*cite journal | author=Menzel HJ, Kane JP, Malloy MJ, Havel RJ |title=A variant primary structure of apolipoprotein C-II in individuals of African descent. |journal=J. Clin. Invest. |volume=77 |issue= 2 |pages= 595–601 |year= 1986 |pmid= 3944271 |doi=
*cite journal | author=Sharpe CR, Sidoli A, Shelley CS, "et al." |title=Human apolipoproteins AI, AII, CII and CIII. cDNA sequences and mRNA abundance. |journal=Nucleic Acids Res. |volume=12 |issue= 9 |pages= 3917–32 |year= 1984 |pmid= 6328445 |doi=
*cite journal | author=Jackson CL, Bruns GA, Breslow JL |title=Isolation and sequence of a human apolipoprotein CII cDNA clone and its use to isolate and map to human chromosome 19 the gene for apolipoprotein CII. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=81 |issue= 10 |pages= 2945–9 |year= 1984 |pmid= 6328478 |doi=PBB_Controls
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