Glutamate-5-semialdehyde dehydrogenase

In enzymology, a glutamate-5-semialdehyde dehydrogenase (EC number|1.2.1.41) is an enzyme that catalyzes the chemical reaction

:L-glutamate 5-semialdehyde + phosphate + NADP⁺ $ightleftharpoons$ L-glutamyl 5-phosphate + NADPH + H⁺

The 3 substrates of this enzyme are L-glutamate 5-semialdehyde, phosphate, and NADP⁺, whereas its 3 products are L-glutamyl 5-phosphate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating). Other names in common use include beta-glutamylphosphate reductase, gamma-glutamyl phosphate reductase, beta-glutamylphosphate reductase, glutamate semialdehyde dehydrogenase, and glutamate-gamma-semialdehyde dehydrogenase. This enzyme participates in urea cycle and metabolism of amino groups.

tructural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1O20, PDB link|1VLU, and PDB link|2H5G.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|54596-29-1."

Gene Ontology (GO) codes