5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase

5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase

In enzymology, a 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase (EC number|1.2.1.60) is an enzyme that catalyzes the chemical reaction

:5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+ ightleftharpoons 5-carboxymethyl-2-hydroxymuconate + NADH + 2 H+

The 3 substrates of this enzyme are 5-carboxymethyl-2-hydroxymuconate semialdehyde, H2O, and NAD+, whereas its 3 products are 5-carboxymethyl-2-hydroxymuconate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 5-carboxymethyl-2-hydroxymuconic-semialdehyde:NAD+ oxidoreductase. This enzyme is also called carboxymethylhydroxymuconic semialdehyde dehydrogenase. This enzyme participates in tyrosine metabolism.

tructural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code PDB link|2D4E.

References

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External links

Gene Ontology (GO) codes


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  • List of EC numbers (EC 1) — This list contains a list of EC numbers for the first group, EC 1, oxidoreducatases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 1.1 Acting on the CH OH …   Wikipedia

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