TSG101

Tumor susceptibility gene 101, also known as TSG101, is a human gene that encodes for a cellular protein of the same name.

PBB_Summary
section_title =
summary_text = The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression. [cite web | title = Entrez Gene: TSG101 tumor susceptibility gene 101| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7251| accessdate = ]

HIV

TSG101 seems to play an important role in the pathogenesis of HIV. In uninfected cells, TSG101 functions in the biogenesis of the multivesicular body (MVB)cite journal |author=Katzmann DJ, Odorizzi G, Emr SD |title=Receptor downregulation and multivesicular-body sorting |journal=Nat. Rev. Mol. Cell Biol. |volume=3 |issue=12 |pages=893–905 |year=2002 |pmid=12461556 |doi=10.1038/nrm973 |issn=] , which suggests that HIV may bind TSG101 in order to gain access to the downstream machinery that catalyzes MVB vesicle budding.cite journal |author=von Schwedler UK, Stuchell M, Müller B, Ward DM, Chung HY, Morita E, Wang HE, Davis T, He GP, Cimbora DM, Scott A, Kräusslich HG, Kaplan J, Morham SG, Sundquist WI |title=The protein network of HIV budding |journal=Cell |volume=114 |issue=6 |pages=701–13 |year=2003 |pmid=14505570 |doi= |url=http://linkinghub.elsevier.com/retrieve/pii/S0092867403007141 |issn=]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Mazzé FM, Degrève L |title=The role of viral and cellular proteins in the budding of human immunodeficiency virus. |journal=Acta Virol. |volume=50 |issue= 2 |pages= 75–85 |year= 2006 |pmid= 16808324 |doi=
*cite journal | author=Freed EO, Mouland AJ |title=The cell biology of HIV-1 and other retroviruses. |journal=Retrovirology |volume=3 |issue= |pages= 77 |year= 2006 |pmid= 17083721 |doi= 10.1186/1742-4690-3-77
*cite journal | author=Li L, Li X, Francke U, Cohen SN |title=The TSG101 tumor susceptibility gene is located in chromosome 11 band p15 and is mutated in human breast cancer. |journal=Cell |volume=88 |issue= 1 |pages= 143–54 |year= 1997 |pmid= 9019400 |doi=
*cite journal | author=Koonin EV, Abagyan RA |title=TSG101 may be the prototype of a class of dominant negative ubiquitin regulators. |journal=Nat. Genet. |volume=16 |issue= 4 |pages= 330–1 |year= 1997 |pmid= 9241264 |doi= 10.1038/ng0897-330
*cite journal | author=Steiner P, Barnes DM, Harris WH, Weinberg RA |title=Absence of rearrangements in the tumour susceptibility gene TSG101 in human breast cancer. |journal=Nat. Genet. |volume=16 |issue= 4 |pages= 332–3 |year= 1997 |pmid= 9241265 |doi= 10.1038/ng0897-332
*cite journal | author=Lee MP, Feinberg AP |title=Aberrant splicing but not mutations of TSG101 in human breast cancer. |journal=Cancer Res. |volume=57 |issue= 15 |pages= 3131–4 |year= 1997 |pmid= 9242438 |doi=
*cite journal | author=Gayther SA, Barski P, Batley SJ, "et al." |title=Aberrant splicing of the TSG101 and FHIT genes occurs frequently in multiple malignancies and in normal tissues and mimics alterations previously described in tumours. |journal=Oncogene |volume=15 |issue= 17 |pages= 2119–26 |year= 1997 |pmid= 9366528 |doi= 10.1038/sj.onc.1201591
*cite journal | author=Xie W, Li L, Cohen SN |title=Cell cycle-dependent subcellular localization of the TSG101 protein and mitotic and nuclear abnormalities associated with TSG101 deficiency. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 4 |pages= 1595–600 |year= 1998 |pmid= 9465061 |doi=
*cite journal | author=Wagner KU, Dierisseau P, Rucker EB, "et al." |title=Genomic architecture and transcriptional activation of the mouse and human tumor susceptibility gene TSG101: common types of shorter transcripts are true alternative splice variants. |journal=Oncogene |volume=17 |issue= 21 |pages= 2761–70 |year= 1998 |pmid= 9840940 |doi= 10.1038/sj.onc.1202529
*cite journal | author=Sun Z, Pan J, Hope WX, "et al." |title=Tumor susceptibility gene 101 protein represses androgen receptor transactivation and interacts with p300. |journal=Cancer |volume=86 |issue= 4 |pages= 689–96 |year= 1999 |pmid= 10440698 |doi=
*cite journal | author=Hittelman AB, Burakov D, Iñiguez-Lluhí JA, "et al." |title=Differential regulation of glucocorticoid receptor transcriptional activation via AF-1-associated proteins. |journal=EMBO J. |volume=18 |issue= 19 |pages= 5380–8 |year= 1999 |pmid= 10508170 |doi= 10.1093/emboj/18.19.5380
*cite journal | author=Rountree MR, Bachman KE, Baylin SB |title=DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci. |journal=Nat. Genet. |volume=25 |issue= 3 |pages= 269–77 |year= 2000 |pmid= 10888872 |doi= 10.1038/77023
*cite journal | author=Bishop N, Woodman P |title=TSG101/mammalian VPS23 and mammalian VPS28 interact directly and are recruited to VPS4-induced endosomes. |journal=J. Biol. Chem. |volume=276 |issue= 15 |pages= 11735–42 |year= 2001 |pmid= 11134028 |doi= 10.1074/jbc.M009863200
*cite journal | author=Li L, Liao J, Ruland J, "et al." |title=A TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback control. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 4 |pages= 1619–24 |year= 2001 |pmid= 11172000 |doi= 10.1073/pnas.98.4.1619
*cite journal | author=VerPlank L, Bouamr F, LaGrassa TJ, "et al." |title=Tsg101, a homologue of ubiquitin-conjugating (E2) enzymes, binds the L domain in HIV type 1 Pr55(Gag). |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 14 |pages= 7724–9 |year= 2001 |pmid= 11427703 |doi= 10.1073/pnas.131059198
*cite journal | author=Garrus JE, von Schwedler UK, Pornillos OW, "et al." |title=Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding. |journal=Cell |volume=107 |issue= 1 |pages= 55–65 |year= 2001 |pmid= 11595185 |doi=
*cite journal | author=Martin-Serrano J, Zang T, Bieniasz PD |title=HIV-1 and Ebola virus encode small peptide motifs that recruit Tsg101 to sites of particle assembly to facilitate egress. |journal=Nat. Med. |volume=7 |issue= 12 |pages= 1313–9 |year= 2002 |pmid= 11726971 |doi= 10.1038/nm1201-1313
*cite journal | author=Demirov DG, Ono A, Orenstein JM, Freed EO |title=Overexpression of the N-terminal domain of TSG101 inhibits HIV-1 budding by blocking late domain function. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 2 |pages= 955–60 |year= 2002 |pmid= 11805336 |doi= 10.1073/pnas.032511899
*cite journal | author=Bennett NA, Pattillo RA, Lin RS, "et al." |title=TSG101 expression in gynecological tumors: relationship to cyclin D1, cyclin E, p53 and p16 proteins. |journal=Cell. Mol. Biol. (Noisy-le-grand) |volume=47 |issue= 7 |pages= 1187–93 |year= 2002 |pmid= 11838966 |doi=
*cite journal | author=Bishop N, Horman A, Woodman P |title=Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein-ubiquitin conjugates. |journal=J. Cell Biol. |volume=157 |issue= 1 |pages= 91–101 |year= 2002 |pmid= 11916981 |doi= 10.1083/jcb.200112080

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes