BACE2

Beta-site APP-cleaving enzyme 2, also known as BACE2, is a human gene.cite web | title = Entrez Gene: BACE2 beta-site APP-cleaving enzyme 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25825| accessdate = ]

BACE2 is a close homolog of BACE1, a protease known to be an important enzyme involved in the cellular pathways that some believe lead to Alzheimer's disease. The physiological function and role of BACE2 in Alzheimer's disease is unknown.

PBB_Summary
section_title =
summary_text = Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein by 2 proteases, one of which is the protein encoded by this gene. This gene localizes to the 'Down critical region' of chromosome 21. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease. Three transcript variants encoding different isoforms have been described for this gene.cite web | title = Entrez Gene: BACE2 beta-site APP-cleaving enzyme 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25825| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Aplin AE, Gibb GM, Jacobsen JS, "et al." |title=In vitro phosphorylation of the cytoplasmic domain of the amyloid precursor protein by glycogen synthase kinase-3beta |journal=J. Neurochem. |volume=67 |issue= 2 |pages= 699–707 |year= 1996 |pmid= 8764598 |doi=
*cite journal | author=Yan R, Bienkowski MJ, Shuck ME, "et al." |title=Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity |journal=Nature |volume=402 |issue= 6761 |pages= 533–7 |year= 1999 |pmid= 10591213 |doi= 10.1038/990107
*cite journal | author=Sadik G, Kaji H, Takeda K, "et al." |title=In vitro processing of amyloid precursor protein by cathepsin D |journal=Int. J. Biochem. Cell Biol. |volume=31 |issue= 11 |pages= 1327–37 |year= 2000 |pmid= 10605825 |doi=10.1016/S1357-2725(99)00053-9
*cite journal | author=Hussain I, Powell D, Howlett DR, "et al." |title=Identification of a novel aspartic protease (Asp 2) as beta-secretase |journal=Mol. Cell. Neurosci. |volume=14 |issue= 6 |pages= 419–27 |year= 2000 |pmid= 10656250 |doi= 10.1006/mcne.1999.0811
*cite journal | author=Lin X, Koelsch G, Wu S, "et al." |title=Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 4 |pages= 1456–60 |year= 2000 |pmid= 10677483 |doi=10.1073/pnas.97.4.1456
*cite journal | author=Acquati F, Accarino M, Nucci C, "et al." |title=The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the down critical region |journal=FEBS Lett. |volume=468 |issue= 1 |pages= 59–64 |year= 2000 |pmid= 10683441 |doi=10.1016/S0014-5793(00)01192-3
*cite journal | author=Bennett BD, Babu-Khan S, Loeloff R, "et al." |title=Expression analysis of BACE2 in brain and peripheral tissues |journal=J. Biol. Chem. |volume=275 |issue= 27 |pages= 20647–51 |year= 2000 |pmid= 10749877 |doi= 10.1074/jbc.M002688200
*cite journal | author=Hattori M, Fujiyama A, Taylor TD, "et al." |title=The DNA sequence of human chromosome 21 |journal=Nature |volume=405 |issue= 6784 |pages= 311–9 |year= 2000 |pmid= 10830953 |doi= 10.1038/35012518
*cite journal | author=Xin H, Stephans JC, Duan X, "et al." |title=Identification of a novel aspartic-like protease differentially expressed in human breast cancer cell lines |journal=Biochim. Biophys. Acta |volume=1501 |issue= 2-3 |pages= 125–37 |year= 2000 |pmid= 10838186 |doi=
*cite journal | author=Farzan M, Schnitzler CE, Vasilieva N, "et al." |title=BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 17 |pages= 9712–7 |year= 2000 |pmid= 10931940 |doi= 10.1073/pnas.160115697
*cite journal | author=Iijima K, Ando K, Takeda S, "et al." |title=Neuron-specific phosphorylation of Alzheimer's beta-amyloid precursor protein by cyclin-dependent kinase 5 |journal=J. Neurochem. |volume=75 |issue= 3 |pages= 1085–91 |year= 2000 |pmid= 10936190 |doi=10.1046/j.1471-4159.2000.0751085.x
*cite journal | author=Solans A, Estivill X, de La Luna S |title=A new aspartyl protease on 21q22.3, BACE2, is highly similar to Alzheimer's amyloid precursor protein beta-secretase |journal=Cytogenet. Cell Genet. |volume=89 |issue= 3-4 |pages= 177–84 |year= 2000 |pmid= 10965118 |doi=10.1159/000015608
*cite journal | author=Hussain I, Powell DJ, Howlett DR, "et al." |title=ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site |journal=Mol. Cell. Neurosci. |volume=16 |issue= 5 |pages= 609–19 |year= 2001 |pmid= 11083922 |doi= 10.1006/mcne.2000.0884
*cite journal | author=Hussain I, Christie G, Schneider K, "et al." |title=Prodomain processing of Asp1 (BACE2) is autocatalytic |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 23322–8 |year= 2001 |pmid= 11316808 |doi= 10.1074/jbc.M101069200
*cite journal | author=Yan R, Munzner JB, Shuck ME, Bienkowski MJ |title=BACE2 functions as an alternative alpha-secretase in cells |journal=J. Biol. Chem. |volume=276 |issue= 36 |pages= 34019–27 |year= 2001 |pmid= 11423558 |doi= 10.1074/jbc.M105583200
*cite journal | author=Grüninger-Leitch F, Schlatter D, Küng E, "et al." |title=Substrate and inhibitor profile of BACE (beta-secretase) and comparison with other mammalian aspartic proteases |journal=J. Biol. Chem. |volume=277 |issue= 7 |pages= 4687–93 |year= 2002 |pmid= 11741910 |doi= 10.1074/jbc.M109266200
*cite journal | author=Turner RT, Loy JA, Nguyen C, "et al." |title=Specificity of memapsin 1 and its implications on the design of memapsin 2 (beta-secretase) inhibitor selectivity |journal=Biochemistry |volume=41 |issue= 27 |pages= 8742–6 |year= 2002 |pmid= 12093293 |doi=10.1021/bi025926t
*cite journal | author=Kim YT, Downs D, Wu S, "et al." |title=Enzymic properties of recombinant BACE2 |journal=Eur. J. Biochem. |volume=269 |issue= 22 |pages= 5668–77 |year= 2003 |pmid= 12423367 |doi=10.1046/j.1432-1033.2002.03277.x
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Kondoh K, Tsuji N, Kamagata C, "et al." |title=A novel aspartic protease gene, ALP56, is up-regulated in human breast cancer independently from the cathepsin D gene |journal=Breast Cancer Res. Treat. |volume=78 |issue= 1 |pages= 37–44 |year= 2003 |pmid= 12611455 |doi=10.1023/A:1022149226430

External links

* http://www.ihop-net.org/UniPub/iHOP/gs/129262.html
*

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes