Magnesium protoporphyrin IX methyltransferase

magnesium protoporphyrin IX methyltransferase
Identifiers
EC number	2.1.1.11
CAS number	9029-82-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a magnesium protoporphyrin IX methyltransferase (EC 2.1.1.11) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + magnesium protoporphyrin IX $\rightleftharpoons$ S-adenosyl-L-homocysteine + magnesium protoporphyrin IX 13-methyl ester

Thus, the two substrates of this enzyme are S-adenosyl methionine and magnesium protoporphyrin IX, whereas its two products are S-adenosylhomocysteine and magnesium protoporphyrin IX 13-methyl ester.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:magnesium-protoporphyrin-IX O-methyltransferase. This enzyme participates in porphyrin and chlorophyll metabolism.

References

• GIBSON KD, NEUBERGER A, TAIT GH (1963). "STUDIES ON THE BIOSYNTHESIS OF PORPHYRIN AND BACTERIOCHLOROPHYLL BY RHODOPSEUDOMONAS SPHEROIDES. 4. S-ADENOSYLMETHIONINEMAGNESIUM PROTOPORPHYRIN METHYLTRANSFERASE". Biochem. J. 88: 325–34. PMC 1202116. PMID 14063871. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1202116. 
• Shepherd M, Reid JD, Hunter CN (2003). "Purification and kinetic characterization of the magnesium protoporphyrin IX methyltransferase from Synechocystis PCC6803". Biochem. J. 371 (Pt 2): 351–60. doi:10.1042/BJ20021394. PMC 1223276. PMID 12489983. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1223276. 
• Bollivar DW, Jiang ZY, Bauer CE, Beale SI (1994). "Heterologous expression of the bchM gene product from Rhodobacter capsulatus and demonstration that it encodes S-adenosyl-L-methionine:Mg-protoporphyrin IX methyltransferase". J. Bacteriol. 176 (17): 5290–6. PMC 196713. PMID 8071204. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=196713. 
• Gibson LC, Hunter CN (1994). "The bacteriochlorophyll biosynthesis gene, bchM, of Rhodobacter sphaeroides encodes S-adenosyl-L-methionine: Mg protoporphyrin IX methyltransferase". FEBS. Lett. 352 (2): 127–30. doi:10.1016/0014-5793(94)00934-1. PMID 7925960. 
• Ebbon JG, Tait GH (1969). "Studies on S-adenosylmethionine-magnesium protoporphyrin methyltransferase in Euglena gracilis strain Z". Biochem. J. 111 (4): 573–82. PMC 1187578. PMID 5774480. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1187578. 

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