5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase

5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase

In enzymology, a 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase (EC number|2.1.1.14) is an enzyme that catalyzes the chemical reaction

:5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine ightleftharpoons tetrahydropteroyltri-L-glutamate + L-methionine

Thus, the two substrates of this enzyme are 5-methyltetrahydropteroyltri-L-glutamatic acid and L-homocysteine, whereas its two products are tetrahydropteroyltri-L-glutamatic acid and L-methionine.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is 5-methyltetrahydropteroyltri-L-glutamate:L-homocysteine S-methyltransferase. Other names in common use include tetrahydropteroyltriglutamate methyltransferase, homocysteine methylase, methyltransferase, tetrahydropteroylglutamate-homocysteine transmethylase, methyltetrahydropteroylpolyglutamate:homocysteine methyltransferase, cobalamin-independent methionine synthase, methionine synthase (cobalamin-independent), and MetE. This enzyme participates in methionine metabolism. It has 2 cofactors: orthophosphate, and zinc.

tructural studies

As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1T7L, PDB link|1U1H, PDB link|1U1J, PDB link|1U1U, PDB link|1U22, PDB link|1XDJ, PDB link|1XPG, PDB link|1XR2, and PDB link|2NQ5.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9068-29-5."

Gene Ontology (GO) codes


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  • List of EC numbers (EC 2) — This list contains a list of EC numbers for the second group, EC 2, transferases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 2.1: Transferring One… …   Wikipedia

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