Neuroprotectin

Neuroprotectin

Neuroprotectin D1 (NPD1) is a docosanoid derived from the polyunsaturated fatty acid (PUFA) docosahexaenoic acid (DHA), which is a component of fish oil and the most important omega-3 PUFA. NPD1 exerts potent anti-inflammatory and anti-apoptotic bioactivity at nanomolar concentrations in a variety of experimental models of brain and retinal diseases. [1]

Neuroprotectins A and B are bicyclohexapeptides.[2]

References

  1. ^ Bazan NG. "Omega-3 fatty acids, pro-inflammatory signaling and neuroprotection.". Curr Opin Clin Nutr Metab Care 10:136-141.. 
  2. ^ Kobayashi H, Shin-Ya K, Nagai K, et al. (2001). "Neuroprotectins A and B, bicyclohexapeptides protecting chick telencephalic neuronal cells from excitotoxicity. I. Fermentation, isolation, physico-chemical properties and biological activity". J. Antibiot. 54 (12): 1013–8. PMID 11858654. 



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