2-dehydropantoate 2-reductase

2-dehydropantoate 2-reductase

In enzymology, a 2-dehydropantoate 2-reductase (EC number|1.1.1.169) is an enzyme that catalyzes the chemical reaction

:(R)-pantoate + NADP+ ightleftharpoons 2-dehydropantoate + NADPH + H+

Thus, the two substrates of this enzyme are (R)-pantoate and NADP+, whereas its 3 products are 2-dehydropantoate, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-pantoate:NADP+ 2-oxidoreductase. Other names in common use include 2-oxopantoate reductase, 2-ketopantoate reductase, 2-ketopantoic acid reductase, ketopantoate reductase, and ketopantoic acid reductase. This enzyme participates in pantothenate and coa biosynthesis.

tructural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1KS9, PDB link|1YJQ, PDB link|1YON, PDB link|2EW2, and PDB link|2OFP.

References

*

External links

::"The CAS registry number for this enzyme class is CAS registry|37211-74-8."

Gene Ontology (GO) codes


Wikimedia Foundation. 2010.

Игры ⚽ Нужно сделать НИР?

Look at other dictionaries:

  • List of EC numbers (EC 1) — This list contains a list of EC numbers for the first group, EC 1, oxidoreducatases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 1.1 Acting on the CH OH …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”