Tropinone reductase II

In enzymology, a tropinone reductase II (EC number|1.1.1.236) is an enzyme that catalyzes the chemical reaction

:pseudotropine + NADP⁺ $ightleftharpoons$ tropinone + NADPH + H⁺

Thus, the two substrates of this enzyme are pseudotropine and NADP⁺, whereas its 3 products are tropinone, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is pseudotropine:NADP+ 3-oxidoreductase. Other names in common use include tropinone (psi-tropine-forming) reductase, pseudotropine forming tropinone reductase, tropinone reductase (ambiguous), and TR-II. This enzyme participates in alkaloid biosynthesis ii.

tructural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1AE1, PDB link|1IPE, PDB link|1IPF, PDB link|1XHL, PDB link|2AE1, and PDB link|2AE2.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|136111-61-0."

Gene Ontology (GO) codes