Estradiol 17beta-dehydrogenase

In enzymology, an estradiol 17beta-dehydrogenase (EC number|1.1.1.62) is an enzyme that catalyzes the chemical reaction

:estradiol-17beta + NAD(P)+ $ightleftharpoons$ estrone + NAD(P)H + H⁺

The 3 substrates of this enzyme are estradiol-17beta, NAD⁺, and NADP⁺, whereas its 4 products are estrone, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is estradiol-17beta:NAD(P)+ 17-oxidoreductase. Other names in common use include 20alpha-hydroxysteroid dehydrogenase, 17beta,20alpha-hydroxysteroid dehydrogenase, 17beta-estradiol dehydrogenase, estradiol dehydrogenase, estrogen 17-oxidoreductase, and 17beta-HSD. This enzyme participates in androgen and estrogen metabolism.

tructural studies

As of late 2007, 29 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1A27, PDB link|1BHS, PDB link|1DHT, PDB link|1EQU, PDB link|1FDS, PDB link|1FDT, PDB link|1FDU, PDB link|1FDV, PDB link|1FDW, PDB link|1GZ6, PDB link|1I5R, PDB link|1IKT, PDB link|1IOL, PDB link|1JTV, PDB link|1QYV, PDB link|1QYW, PDB link|1QYX, PDB link|1S1P, PDB link|1S1R, PDB link|1S2A, PDB link|1S2C, PDB link|1XF0, PDB link|1YB1, PDB link|1ZQ5, PDB link|2F38, PDB link|2FGB, PDB link|2HQ1, PDB link|2PD6, and PDB link|3DHE.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9028-61-9."

Gene Ontology (GO) codes