Prodine

Prodine

drugbox
IUPAC_name = (1,3-dimethyl-4-phenylpiperidin-4-yl) propanoate



width = 160
CAS_number = 77-20-3
CAS_supplemental = 468-59-7 (beta)
synonyms = Prodine, Prisilidine, Nisentil
ATC_prefix =
ATC_suffix =
PubChem = 6471
DrugBank =
C = 16 | H = 23 | N = 1 | O = 2
molecular_weight = 261.359 g/mol
bioavailability =
protein_bound =
metabolism =
elimination_half-life =
excretion =
pregnancy_AU =
pregnancy_US =
pregnancy_category=
legal_AU =
legal_CA =
legal_UK =
legal_US =
legal_status =
routes_of_administration =

Prodine (Prisilidine, Nisentil) is an opioid analgesic that is an analogue of pethidine (meperidine).

There are two isomers of prodine, Alphaprodine and Betaprodine. [Beckett AH, Walker J. The configuration of alphaprodine and betaprodine. Journal of Pharmacy and Pharmacology. 1955 Dec;7(12):1039-45.] Betaprodine is some 5x more potent than alphaprodine, [John Bedford Stenlake. Foundations of Molecular Pharmacology. ISBN 0-485-11171-3] but is metabolised more rapidly, and only alphaprodine was developed for medicinal use. It has similar activity to pethidine, but with a faster onset of action and shorter duration. [Fung DL, Asling JH, Eisele JH, Martucci R. A comparison of alphaprodine and meperidine pharmacokinetics. "Journal of Clinical Pharmacology". 1980 Jan;20(1):37-41.]

Alphaprodine was sold under several brand names, mainly Nisentil and Prisilidine. It was mainly used for pain relief in childbirth [Burnett RG, White CA. Alphaprodine for continuous intravenous obstetric analgesia. "Obstetrics and Gynecology". 1966 Apr;27(4):472-7.] and dentistry, [Carter WJ, Bogert JA. An effective pre-medication procedure for dental patients. "Journal of the Missouri Dental Association". 1966 Jun-Jul;46(6):8-9.] as well as for minor surgical procedures.

Prodine has similar effects to other opioids, and produces analgesia, sedation and euphoria. Side effects can include itching, nausea and potentially serious respiratory depression which can be life-threatening. Respiratory depression can be a problem with alphaprodine even at normal therapeutic doses. [Fuller JD, Crombleholme WR. Respiratory arrest and prolonged respiratory depression after one low, subcutaneous dose of alphaprodine for obstetric analgesia. A case report. "Journal of Reproductive Medicine". 1987 Feb;32(2):149-51.]

References


Wikimedia Foundation. 2010.

Игры ⚽ Поможем решить контрольную работу

Look at other dictionaries:

  • prodine — noun A particular narcotic painkiller …   Wiktionary

  • α-prodine hydrochloride — See alphaprodine …   Medical dictionary

  • Opioid — Endogenous opioid peptides Skeletal molecular images Adrenorphin Amidorphin Casomorphin …   Wikipedia

  • Morphine — This article is about the drug. For other meanings, see Morphine (disambiguation). Morphia redirects here. For other uses, see Morphia (disambiguation). Not to be confused with Morphinae, Morphea, or Morpholine. Morphine …   Wikipedia

  • Opiate — For other uses see Opiate (disambiguation), or for the class of drugs see Opioid. Harvesting the poppy pod. In medicine, the term opiate describes any of the narcotic opioid alkaloids found as natural products in the opium poppy plant …   Wikipedia

  • Phencyclidine — Systematic (IUPAC) name …   Wikipedia

  • Loperamide — Imodium redirects here. For the song by Nirvana, see Breed (song). Loperamide Systematic (IUPAC) name …   Wikipedia

  • Pethidine — Systematic (IUPAC) name …   Wikipedia

  • Opioid receptor — Opioid receptors are a group of G protein coupled receptors with opioids as ligands.[1][2][3] The endogenous opioids are dynorphins, enkephalins, endorphins, endomorphins and nociceptin. The opioid receptors are 40% identical to somatostatin… …   Wikipedia

  • Oxymorphone — Systematic (IUPAC) name 4,5α epoxy 3,14 dihydroxy 17 methylmorphinan 6 one Clinical data Trade names …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”