Etoxadrol

Etoxadrol

Drugbox
IUPAC_name = (2S)-2- [(2S,4S)-2-ethyl-2-phenyl-1,3-dioxolan-4-yl] piperidine



width= 150
CAS_number= 28189-85-7
ATC_prefix=
ATC_suffix=
PubChem= 19324
DrugBank=
C=16 | H=23 | N=1 | O=2
molecular_weight = 261.36 g/mol
bioavailability=
metabolism =
elimination_half-life=
excretion =
pregnancy_category =
legal_status = Legal
routes_of_administration=

Etoxadrol is a dissociative anaesthetic drug which has been found to be an NMDA antagonist and produces similar effects to PCP in animals. [Thurkauf A, Zenk PC, Balster RL, May EL, George C, Carroll FI, Mascarella SW, Rice KC, Jacobson AE, Mattson MV. Synthesis, absolute configuration, and molecular modeling study of etoxadrol, a potent phencyclidine-like agonist. "Journal of Medicinal Chemistry". 1988 Dec;31(12):2257-63.] [Thurkauf A, Mattson MV, Richardson S, Mirsadeghi S, Ornstein PL, Harrison EA Jr, Rice KC, Jacobson AE, Monn JA. Analogues of the dioxolanes dexoxadrol and etoxadrol as potential phencyclidine-like agents. Synthesis and structure-activity relationships. "Journal of Medicinal Chemistry". 1992 Apr 17;35(8):1323-9.] Etoxadrol, along with another related drug dexoxadrol, were developed as analgesics for use in humans, but development was discontinued after patients reported side effects such as nightmares and hallucinations. [Sax M, Wunsch B. Relationships between the structure of dexoxadrol and etoxadrol analogues and their NMDA receptor affinity. "Current Topics in Medicinal Chemistry". 2006;6(7):723-32.] [Aepkers M, Wunsch B. Structure-affinity relationship studies of non-competitive NMDA receptor antagonists derived from dexoxadrol and etoxadrol. "Bioorganic and Medicinal Chemistry". 2005 Dec 15;13(24):6836-49.]

References


Wikimedia Foundation. 2010.

Игры ⚽ Нужен реферат?

Look at other dictionaries:

  • Dexoxadrol — Systematic (IUPAC) name (2S) 2 [(4S) 2,2 di(phenyl) 1,3 dioxolan 4 yl]piperidine Clinical data Pregnancy cat.  ? …   Wikipedia

  • Phencyclidine — Systematic (IUPAC) name …   Wikipedia

  • Toluene — IUPAC name …   Wikipedia

  • Dizocilpine — Systematic (IUPAC) name (+) 5 methyl 10,11 dihydro 5H dibenzo[a,d]cyclohepten 5,10 imine maleate Clinical data Pregnancy cat …   Wikipedia

  • Dextrorphan — Systematic (IUPAC) name (+) 17 methyl 9a,13a,14a morphinan 3 ol …   Wikipedia

  • Dextromethorphan — Not to be confused with Dexamethasone. Dextromethorphan Systematic (IUP …   Wikipedia

  • Methorphan — Systematic (IUPAC) name 3 methoxy 17 methylmorphinan Clinical data Pregnancy cat.  ? Legal status  ? Identifiers CAS number …   Wikipedia

  • NMDA receptor antagonist — Ketamine, one of the most common NMDA receptor antagonists. NMDA receptor antagonists are a class of anesthetics that work to antagonize, or inhibit the action of, the N methyl d aspartate receptor (NMDAR). They are used as anesthesia for animals …   Wikipedia

  • Neramexane — Systematic (IUPAC) name 1,3,3,5,5 pentamethylcyclohexanamine Clinical data Pregnancy cat.  ? …   Wikipedia

  • Dieticyclidine — Systematic (IUPAC) name N,N diethyl 1 phenylcyclohexan 1 amine Clinical data Pregnancy cat.  ? …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”