Valofane

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IUPAC_name = N-carbamoyl-5-methyl-2-oxo-3-prop-2-enyloxolane-3-carboxamide


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CAS_number = 3258-51-3
synonyms = Valofan, Valofane
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PubChem = 71122
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C=10 | H=14 | N= 2 | O=4
molecular_weight = 226.229 g/mol
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Valofane is a sedative drug structurally related to the barbiturates [Traversa U, Puppini P, Jacquot C, Vertua R. Effect of an atypical barbiturate, the 2-allophanyl-2-allyl-4-valerolactone (valofan), on exploratory behaviour and brain serotonin concentrations in mice. "Journal de Pharmacologie". 1985 Jul-Sep;16(3):279-90.] and similar drugs such as primidone. It is metabolised once inside the body to form the barbiturate proxibarbal and is thus a prodrug. [Lambrey B, Compagnon PL, Jacquot C. Pharmacokinetics of 14C-2-allophanyl-2-allyl -gamma-valero-lactone: a prodrug of proxibarbal in rats. "European Journal of Drug Metabolism and Pharmacokinetics". 1981;6(3):161-9.]

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