- Krapcho decarboxylation
The Krapcho decarboxylation is the
chemical reaction ofester s withhalide anion s. The ester must contain anelectron-withdrawing group in the beta position, such as β-ketoesters, malonic esters, α-cyanoesters, or α-sulfonylesters. [Krapcho, A. P.; Glynn, G. A.; Grenon, B. J. "Tetrahedron Lett. " 1967, "8", 215.] [Flynn, D. L.; Becker, D. P.; Nosal, R.; Zabrowski, D. L. "Tetrahedron Lett. " 1992, "33", 7283.]References
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