P57 (gene)

p57 or p57KIP2 is a tumor suppressor human gene on chromosome 11 (11p15) and belongs to the "cip/kip" gene family. It encodes a cell cycle inhibitor that binds to G1 cyclin-CDK complexes. [ [http://www.genesdev.org/cgi/content/abstract/9/6/650 p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene.] GENES & DEVELOPMENT 9:650-662, 1995. ISSN 0890-9369. ] Thus p57KIP2 causes arrest of the cell cycle in G1 phase. A mutation of this gene may lead to loss of control over the cell cycle leading to uncontrolled cellular proliferation. p57KIP2 has been associated with Beckwith-Wiedemann syndrome (BWS) which is characterized by increased risk of tumor formation in childhood. [ [http://www.springerlink.com/content/4qe329xf1p43rgjc/ New p57KIP2 mutations in Beckwith-Wiedemann syndrome] Human Genetics, Vol 100, Num 5-6 / Sept 1997. ]

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