Norspermidine

Norspermidine
Norspermidine
Identifiers
CAS number 56-18-8 YesY
ChEMBL CHEMBL28743 N
Jmol-3D images Image 1
Properties
Molecular formula C6H17N3
Molar mass 131.22 g/mol
Appearance Clear, colorless liquid
Density 0.9380 g/cm³, liquid
Melting point

−14 °C, 259 K, 7 °F

Boiling point

235 °C, 508 K, 455 °F

Hazards
MSDS Norspermidine MSDS
Flash point 118 °C (244.4 °F)
Autoignition
temperature
280 °C (536 °F)
 N (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Norspermidine is a polyamine of similar structure to the more common spermidine. While norspermidine has been found to occur naturally in some species of plants,[1][2] bacteria,[3] and algae,[4] it is not known to be a natural product in humans as spermidine is.

Norspermidine is being researched for its use as an antitumor medicine in cancer treatment.[5][6]

References

  1. ^ Rodriguez-Garay, B et al. (1989). "Detection of Norspermidine and Norspermine in Medicago sativa L. (Alfalfa)". Plant Physiology 89 (2): 525–529. doi:10.1104/pp.89.2.525. PMC 1055875. PMID 16666576. ISSN: 0032-0889. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1055875. 
  2. ^ Hamana, K et al. (1998). "Unusual polyamines in aquatic plants: the occurrence of homospermidine, norspermidine, thermospermine, norspermine, aminopropylhomospermidine, bis(aminopropyl)ethanediamine, and methylspermidine". Can. J. Bot. 76 (1): 130–133. doi:10.1139/cjb-76-1-130. 
  3. ^ Yamamoto, S et al. (Apr. 27, 1979). "Occurrence of norspermidine in some species of genera Vibrio and Beneckea". Biochem Biophys Res Commun. 87 (4): 1102–1108. doi:10.1016/S0006-291X(79)80021-2. PMID 313792. 
  4. ^ Hamana, K; Matsuzaki, S (1982). "Widespread Occurrence of Norspermidine and Norspermine in Eukaryotic Algae". J. Biochem 91 (4): 1321–1328. PMID 7096289. ISSN: 0021-924X. 
  5. ^ Prakash, NJ et al. (1988). "Antitumor activity of norspermidine, a structural homologue of the natural polyamine spermidine". Anticancer Res. 8 (4): 563–568. PMID 3140710. 
  6. ^ Sunkara, PS et al. (1988). "Mechanism of antitumor activity of norspermidine, a structural homologue of spermidine". Adv Exp Med Biol. 250: 707–716. PMID 3255245. 

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Look at other dictionaries:

  • norspermidine — noun The triamine N (3 aminopropyl)propane 1,3 diamine that occurs in some plants and bacteria See Also: spermidine …   Wiktionary

  • Sym-norspermidine synthase — In enzymology, a sym norspermidine synthase (EC number|2.5.1.23) is an enzyme that catalyzes the chemical reaction:S adenosylmethioninamine + propane 1,3 diamine ightleftharpoons 5 methylthioadenosine + bis(3 aminopropyl)amineThus, the two… …   Wikipedia

  • List of EC numbers (EC 2) — This list contains a list of EC numbers for the second group, EC 2, transferases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 2.1: Transferring One… …   Wikipedia

  • spermidine — noun The triamine N (3 aminopropyl)butane 1,4 diamine, originally obtained from semen, that is involved in cell metabolism. See Also: norspermidine …   Wiktionary

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