Betaglycan

protein
Name=transforming growth factor, beta receptor III
caption=


width=
HGNCid=11774
Symbol=TGFBR3
AltSymbols=
EntrezGene=7049
OMIM=600742
RefSeq=NM_003243
UniProt=Q03167
PDB=
ECnumber=
Chromosome=1
Arm=p
Band=33
LocusSupplementaryData=-p32

Betaglycan is a cell-surface chondroitin sulfate / heparan sulfate proteoglycan >300 kDa in molecular weight. Betaglycan binds to various members of the TGF-beta superfamily of ligands via its core protein, and bFGF via its heparan sulfate chains. It is not involved directly in TGF-beta signal transduction but by binding to various member of the TGF-beta superfamily at the cell surface it acts as a reservoir of ligand for TGF-beta receptors. [cite journal | author= Andres JL, Stanley K. "et al". | title= Membrane-anchored and soluble forms of betaglycan, a polymorphic proteoglycan that binds transforming growth factor-beta | journal= J. Cell Biol. | year=1989 | volume=109 | issue=6 (Pt 1) | pages= 3137-3145 | pmid = 2592419] [cite journal | author= Andres JL, DeFalcis D. "et al". | title= Binding of two growth factor families to separate domains of the proteoglycan betaglycan | journal= J. Biol. Chem. | year=1992 | volume=267 | issue=9 | pages=5927-5930 | pmid =1556106]

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