Small nucleolar RNA snR66

snoRNA snR66 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifiying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.snoRNA snR66 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs [cite journal | last = Galardi | first = S | coauthors = Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I | year = 2002 | title = Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro | journal = Mol Cell Biol | volume = 22 | pages = 6663–6668 | pmid = 12215523 | doi = 10.1128/MCB.22.19.6663-6668.2002] .snoRNA snR66 was initially discovered using a computational screen of the "Saccharomyces cerevisiae" genomecite journal |author=Lowe TM, Eddy SR |title=A computational screen for methylation guide snoRNAs in yeast |journal=Science |volume=283 |issue=5405 |pages=1168–71 |year=1999 |pmid=10024243 |doi=] .

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* [http://people.biochem.umass.edu/sfournier/fournierlab/snornadb/snrs/snr66_ta.php Link to snR66 at the FournierLab's snoRNAdb.]