Histone 3' UTR stem-loop

Histone 3' UTR stem-loop

The Histone 3' UTR stem-loop is an RNA element involved in nucleocytoplasmic transport of the mRNA, and in stability regulation and translation efficiency in the cytoplasm. The mRNAs of metazoan histone genes lack a poly-A tail. 3' end processing occurs at a site between this highly conserved stem-loop and a purine rich region around 20 nucleotides downstream (the histone downstream element, or HDE). The stem-loop is bound by a 31 kDa stem-loop binding protein (SLBP - also termed the histone hairpin binding protein, or HBP). Together with U7 snRNA binding of the HDE, SLBP binding nucleates the formation of the processing complex.

References

* [1] cite journal | last = Williams | first = AS | coauthors = Marzluff WF | year = 1995 | title = The sequence of the stem and flanking sequences at the 3' end of histone mRNA are critical determinants for the binding of the stem-loop binding protein | journal = Nucleic Acids Res | volume = 23 | pages = 654–662 | pmid = 7899087 | doi = 10.1093/nar/23.4.654
* [2] cite journal | last = Dominski | first = Z | coauthors = Marzluff WF | year = 1999 | title = Formation of the 3' end of histone mRNA | journal = Gene | volume = 239 | pages = 1–14 | pmid = 10571029 | doi = 10.1016/S0378-1119(99)00367-4

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