Picornavirus internal ribosome entry site (IRES)
- Picornavirus internal ribosome entry site (IRES)
This family represents the Picornavirus internal ribosome entry site (IRES). IRES elements allow cap and end-independent translation of mRNA in the host cell. It has been found that La autoantigen (La) is required for Coxsackievirus B3 (CVB3) IRES-mediated translation, and it has been suggested that La may be required for the efficient translation of the viral RNA in the pancreas. [cite journal | last = Ray | first = PS | coauthors = Das S | year = 2002 | title = La autoantigen is required for the internal ribosome entry site-mediated translation of Coxsackievirus B3 RNA | journal = Nucleic Acids Res | volume = 30 | pages = 4500–4508 | pmid = 12384597 | doi = 10.1093/nar/gkf583] [cite journal | last = Liu | first = Z | coauthors = Carthy CM, Cheung P, Bohunek L, Wilson JE, McManus BM, Yang D | year = 1999 | title = Structural and functional analysis of the 5' untranslated region of coxsackievirus B3 RNA: In vivo translational and infectivity studies of full-length mutants | journal = Virology | volume = 265 | pages = 206–217 | pmid = 10600593 | doi = 10.1006/viro.1999.0048]
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