Tiazofurin

Tiazofurin

Chembox new
ImageFile=Tiazofurin.pngImageSize=200px
IUPACName=2- [("2R,3R,4S,5R")-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl] -1,3-thiazole-4-carboxamide
OtherNames=
Section1= Chembox Identifiers
CASNo=60084-10-8
PubChem=457954
SMILES=C1=C(N=C(S1) [C@H] 2 [C@@H] ( [C@@H] ( [C@H] (O2)CO)O)O)C(=O)N
MeSHName=Tiazofurin

Section2= Chembox Properties
Formula=C9H12N2O5S
MolarMass=260.268
Appearance=
Density=
MeltingPt=
BoilingPt=
Solubility=

Section3= Chembox Hazards
MainHazards=
FlashPt=
Autoignition=

Tiazofurin is an inhibitor of IMP dehydrogenase. Tiazofurin and its analogues are under investigation for potential use in the treatment of cancer. [cite journal |author=Popsavin M, Torović L, Svircev M et al |title=Synthesis and antiproliferative activity of two new tiazofurin analogues with 2'-amido functionalities |journal=Bioorg. Med. Chem. Lett. |volume=16 |issue=10 |pages=2773–6 |year=2006 |pmid=16495053 |doi=10.1016/j.bmcl.2006.02.001]

References


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