RAMP1

RAMP1

protein
Name = receptor (G protein-coupled) activity modifying protein 1
caption =


width =
HGNCid = 9843
Symbol = RAMP1
AltSymbols =
EntrezGene = 10267
OMIM = 605153
RefSeq = NM_005855
UniProt = O60894
PDB =
ECnumber =
Chromosome = 2
Arm = q
Band = 36
LocusSupplementaryData = -q37.1

Receptor activity modifying protein 1, also known as RAMP1, is a human gene.cite web | title = Entrez Gene: RAMP1 | url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10267 | accessdate =] cite journal | author =McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM | title = RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor | journal = Nature | volume = 393 | issue = 6683 | pages = 333–9 | year = 1998 | month = May | pmid = 9620797 | doi = 10.1038/30666 | url = | issn = ]

The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface.

References


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