Epoxide hydrolase

Epoxide hydrolase

protein
Name= epoxide hydrolase 1, microsomal (xenobiotic)
caption=


width=
HGNCid=3401
Symbol=EPHX1
AltSymbols=EPHX
EntrezGene=2052
OMIM=132810
RefSeq=NM_000120
UniProt=P07099
PDB=
ECnumber=3.3.2.3
Chromosome=1
Arm=q
Band=42.1
LocusSupplementaryData=
protein
Name=epoxide hydrolase 2, cytoplasmic
caption=


width=
HGNCid=3402
Symbol=EPHX2
AltSymbols=
EntrezGene=2053
OMIM=132811
RefSeq=NM_001979
UniProt=P34913
PDB=
ECnumber=
Chromosome=8
Arm=p
Band=21
LocusSupplementaryData=

Epoxide hydrolase (also known as Epoxide hydratase) functions in detoxication during drug metabolism.It converts epoxides from the degradation of aromatic compounds to trans-dihydrodiols which can be conjugated and excreted from the body.

Epoxides are significant as cytochrome P450 oxidase metabolites of unsaturated carbon-carbon bonds, but are also mutagenic. Epoxide hydrolase is present in large quantity on endoplasmic reticulum.

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