Cipemastat

Cipemastat: Cipemastat

IUPAC name

(2R,3R)-3-(cyclopentylmethyl)-N-hydroxy-4-oxo-4-(piperidin-1-yl)-2-[(3,4,4-trimethyl-2,5-dioxoimidazolidin-1-yl)methyl]butanamide

Identifiers

CAS number 190648-49-8^Y

PubChem 9824350

ChEMBL CHEMBL467686^N

Jmol-3D images Image 1

SMILES

CC1(C)NC(=O)N(C[C@@H]([C@@H](CC2CCCC2)C(=O)N3CCCCC3)C(=O)NO)C1=O

Properties

Molecular formula C₂₂H₃₆N₄O₅

Molar mass 436.55 g mol⁻¹

N (verify) (what is: Y/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)

Infobox references

Cipemastat (rINN, also known as Ro 32-3555 and by the tentative trade name Trocade) is a selective inhibitor of matrix metalloproteinase-1 that has been investigated as an anti-arthritis agent.^[1] It is being developed by Roche.

References

^ Hemmings F, Farhan M, Rowland J, Banken L, Jain R (2001). "Tolerability and pharmacokinetics of the collagenase-selective inhibitor Trocade in patients with rheumatoid arthritis". Rheumatology (Oxford) 40 (5): 537–43. doi:10.1093/rheumatology/40.5.537. PMID 11371662.

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Academic Dictionaries and Encyclopedias

Cipemastat

IUPAC name (2R,3R)-3-(cyclopentylmethyl)-N-hydroxy-4-oxo-4-(piperidin-1-yl)-2-[(3,4,4-trimethyl-2,5-dioxoimidazolidin-1-yl)methyl]butanamide
Identifiers
CAS number	190648-49-8^Y
PubChem	9824350
ChEMBL	CHEMBL467686^N
Jmol-3D images	Image 1
SMILES CC1(C)NC(=O)N(C[C@@H]([C@@H](CC2CCCC2)C(=O)N3CCCCC3)C(=O)NO)C1=O
Properties
Molecular formula	C₂₂H₃₆N₄O₅
Molar mass	436.55 g mol⁻¹
N (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references