Transferrin receptor

Transferrin receptor

protein
Name= transferrin receptor (p90, CD71)
caption=


width=
HGNCid=11763
Symbol=TFRC
AltSymbols=CD71, TFR1
EntrezGene=7037
OMIM=190010
RefSeq=NM_003234
UniProt=P02786
PDB=
ECnumber=
Chromosome=3
Arm=q
Band=29
LocusSupplementaryData=protein
Name= transferrin receptor 2
caption=


width=
HGNCid=11762
Symbol=TFR2
AltSymbols=HFE3, TFRC2
EntrezGene=7036
OMIM=604720
RefSeq=NM_003227
UniProt=Q9UP52
PDB=
ECnumber=
Chromosome=7
Arm=q
Band=22
LocusSupplementaryData=

Transferrin receptor (TfR) is a carrier protein for transferrin. It's needed for the import of iron into the cell and it's regulated in response to intracellular iron concentration. Thus, it maintains cellular iron homeostasis.

TfR production in the cell is regulated according to iron levels by iron response/regulatory element binding protein (IRE-BP). This protein binds to the hairpin like structure (IRE) that is in the 3' UTR of the TfR receptor. Once binding occurs, degradation of mRNA of IRE is inhibited.

ee also

* TFR2
* TFRC

External links

*
* http://sickle.bwh.harvard.edu/iron_transport.html
* http://www.miltenyibiotec.com/en/PG_595_386_CD71.aspx
*http://www.jbc.org/cgi/content/abstract/266/21/13925
* http://www.ncbi.nlm.nih.gov/pubmed/16904380
* http://www.ncbi.nlm.nih.gov/pubmed/16920030
* http://www.sciencedirect.com/science?_ob=MiamiCaptionURL&_method=retrieve&_udi=B6WCJ-4KM46WH-2&_


Wikimedia Foundation. 2010.

Игры ⚽ Нужно решить контрольную?

Look at other dictionaries:

  • Transferrin — is a blood plasma protein for iron ion delivery. Transferrin is a glycoprotein, which binds iron very tightly but reversibly. Although iron bound to transferrin is less than 0.1% (4 mg) of the total body iron, dynamically it is the most important …   Wikipedia

  • Transferrin-Rezeptor 2 — Masse/Länge Primärstruktur 801/630/774 Aminosäuren (α/β/γ) …   Deutsch Wikipedia

  • Receptor (biochemistry) — For other uses, see Receptor (disambiguation). In biochemistry, a receptor is a molecule found on the surface of a cell, which receives specific chemical signals from neighbouring cells or the wider environment within an organism. These signals… …   Wikipedia

  • [effect on ischemic myocardial injury]; total flow resistance; traditional functional retraining; transferrin receptor — testicular feminization syndrome; thyroid function study; tube fed saline …   Medical dictionary

  • Receptor-mediated endocytosis — Mechanism of clathrin dependent endocytosis. Receptor mediated endocytosis (RME), also called clathrin dependent endocytosis, is a process by which cells internalize molecules (endocytosis) by the inward budding of plasma membrane vesicles… …   Wikipedia

  • Cell surface receptor — The seven transmembrane α helix structure of a G protein coupled receptor Cell surface receptors (membrane receptors, transmembrane receptors) are specialized integral membrane proteins that take part in communication between the cell and the… …   Wikipedia

  • Olfactory receptor — Olfactory receptors expressed in the cell membranes of olfactory receptor neurons are responsible for the detection of odor molecules. Activated olfactory receptors are the initial player in a signal transduction cascade which ultimately produces …   Wikipedia

  • Neurotransmitter receptor — Figure 1. The seven transmembrane α helix structure of a G protein coupled receptor. A Neurotransmitter receptor is a membrane receptor protein[1] that is activated by a Neurotransmitter …   Wikipedia

  • Tumor necrosis factor receptor — TNFR/NGFR cysteine rich region Structure of the soluble human 55 kd TNF receptor human TNF beta complex[1]. Identifiers Symbol …   Wikipedia

  • Eicosanoid receptor — An eicosanoid receptor is an integral membrane protein which detects the presence of eicosanoid signaling molecules. Most, though not all, are G protein coupled receptors (GPCRs). An example of a non GPCR receptor that binds eicosanoids is PPAR γ …   Wikipedia

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”