Crotamiton

Crotamiton

Systematic (IUPAC) name
(E)-N-Ethyl-N-(2-methylphenyl)but-2-enamide[1]
Clinical data
AHFS/Drugs.com	monograph
Pregnancy cat.	C
Legal status	?
Identifiers
CAS number	483-63-6 Y
ATCvet code	QP53AX04
PubChem	CID 688020
DrugBank	DB00265
ChemSpider	599515 Y
UNII	D6S4O4XD0H Y
KEGG	D01381 Y
ChEMBL	CHEMBL1200709 N
Chemical data
Formula	C13H17NO
Mol. mass	203.28 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C13H17NO/c1-4-8-13(15)14(5-2)12-10-7-6-9-11(12)3/h4,6-10H,5H2,1-3H3/b8-4+ Y Key:DNTGGZPQPQTDQF-XBXARRHUSA-N Y
N(what is this?)  (verify)

Crotamiton is a drug that is used both as a scabicidal (for treating scabies) and as a general antipruritic (anti-itching drug). It is a prescription and OTC lotion based medicine that is applied to the whole body to get rid of the scabies parasite that burrows under the skin and causes itching.

Use

For treating scabies, crotamiton should be applied to the whole body rather than a localized area. It is applied 2 to 3 times, with a 24 hour delay in between applications, and the patient is asked to take a shower no sooner than after 48 hours. For children under 3 years it is applied once daily. Crotamiton can also be used to treat itching stemming from other causes, e.g. insect bites, in which case it is applied to the itching areas only, and repeated if necessary after 4 to 8 hours. Use near the eyes, or breaks in the skin, should be avoided.

Pharmacology

The mechanism of action of crotamiton is unknown, but it is toxic to the scabies mite.^[2]

Pharmacokinetics

After topical application, crotamiton is absorbed systemically. It has an elimination half-life of 30.9 hours and 4.8-8.8% is excreted in the urine.^[3]

Side effects

The most common side effect of crotamiton is skin irritation.

Trade name

Crotamiton is marketed under the trade names Eurax, which is manufactured by Novartis in the UK, and Euracin, which is manufactured by Green Cross in South Korea.

References

1. ^ Crotamiton at alanwood.net
2. ^ Medscape drug information - mechanism of action
3. ^ Medscape drug information - pharmacokinetics

This antiinfective drug article is a stub. You can help Wikipedia by expanding it.v · Categories: Drugs Antiinfective agent stubs Wikimedia Foundation. 2010. Игры ⚽ Поможем решить контрольную работу Mercedes Tenorio Hesaka Station Look at other dictionaries: crotamitón — Escabicida prescrito para el tratamiento de la sarna y de otras enfermedades pruriginosas de la piel. Diccionario Mosby Medicina, Enfermería y Ciencias de la Salud, Ediciones Hancourt, S.A. 1999 …   Diccionario médico crotamiton — A sarcopticide for topical use in scabies. * * * n. a drug that destroys mites and is used to treat scabies and similar skin infections and also to relieve itching. It is applied to the skin as a lotion or ointment and sometimes causes reddening… …   Medical dictionary crotamiton — n. a drug that is used to relieve itching, including that associated with scabies. It is applied to the skin as a lotion or cream and sometimes causes reddening and hypersensitivity reactions. Trade names: Eurax …   The new mediacal dictionary Кротамитон (Crotamiton) — лекарственное вещество, которое уничтожает клещей; применяется для лечения струпьев и аналогичных кожных инфекционных заболеваний, а также для уменьшения зуда. Наносится на поверхность кожи в виде лосьона или мази; иногда может вызвать… …   Медицинские термины КРОТАМИТОН — (crotamiton) лекарственное вещество, которое уничтожает клещей; применяется для лечения струпьев и аналогичных кожных инфекционных заболеваний, а также для уменьшения зуда. Наносится на поверхность кожи в виде лосьона или мази; иногда может… …   Толковый словарь по медицине Scabies — Classification and external resources A photomicrograph of an itch mite (Sarcoptes scabiei). ICD 10 B …   Wikipedia Отоакариаз — Otobius megnini Ушной акариаз (Otoacariasis) тропический акариаз, вызванный паразитированием клещей в ушах человека. Содержание 1 Эпидемиология …   Википедия Disulfiram — Systematic (IUPAC) name 1,1 ,1 ,1 [disulfanediylb …   Wikipedia Itch — For other uses, see Itch (disambiguation). Pruritus Classification and external resources A man trying to reach for an itch ICD 10 L …   Wikipedia Lindane — Systematic (IUPAC) name (1r,2R,3S,4r,5R,6S) 1,2,3,4,5,6 hexachlorocyclohexane Clinical data …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”