Gemfibrozil

Gemfibrozil
Gemfibrozil
Systematic (IUPAC) name
5-(2,5-dimethylphenoxy)-2,2-dimethyl-pentanoic acid
Clinical data
Trade names Lopid
AHFS/Drugs.com monograph
MedlinePlus a686002
Pregnancy cat. Category C
Legal status By Prescription
Routes Oral
Pharmacokinetic data
Bioavailability Close to 100%
Protein binding 95%
Metabolism Hepatic (CYP3A4)
Half-life 1.5 hours
Excretion Renal 94%
Feces 6%
Identifiers
CAS number 25812-30-0 YesY
ATC code C10AB04
PubChem CID 3463
DrugBank APRD00293
ChemSpider 3345 YesY
UNII Q8X02027X3 YesY
KEGG D00334 YesY
ChEBI CHEBI:5296 YesY
ChEMBL CHEMBL457 YesY
Chemical data
Formula C15H22O3 
Mol. mass 250.333 g/mol
SMILES eMolecules & PubChem
 N(what is this?)  (verify)

Gemfibrozil is the generic name for an oral drug used to lower lipid levels. It belongs to a group of drugs known as fibrates. It is most commonly sold as the brand name, Lopid. Other brand names include Jezil and Gen-Fibro.

Contents

Actions

Therapeutic effects

  • Reduce triglyceride levels
  • Reduce Very low density lipoprotein (VLDL) levels
  • Modest reduction of Low density lipoprotein (LDL) levels
  • Moderate increase in High density lipoprotein (HDL) levels

Nontherapeutic effects and toxicities

Indications

Contraindications and Precautions

  • Gemfibrozil should not be given to these patients:
    • Hepatic dysfunction
    • Renal dysfunction
  • Gemfibrozil should be used with caution in these higher risk categories:
    • Biliary Tract Disease
    • Pregnant women
    • Obese patients
    • Native Americans

Drug Interactions

  • Anticoagulants: Gemfibrozil potentiates the action of coumadin and indanedione anticoagulants.
  • Statin drugs: Concomitant administration of fibrates (including gemfibrozil) with statin drugs increases the risk of muscle cramping, myopathy, and rhabdomyolysis.

External links


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Look at other dictionaries:

  • Gemfibrozil — Nombre (IUPAC) sistemático 5 (2,5 dimethylphenoxy) 2,2 dimethyl pentanoic acid Identificadores …   Wikipedia Español

  • gemfibrozil — fármaco hipolipemiante utilizado en el tratamento de las dislipidemias estructura química [véase http://www.iqb.es/diccio/g/ge.htm#gemfibrozil] Diccionario ilustrado de Términos Médicos.. Alvaro Galiano. 2010. gemfibrozil Agente a …   Diccionario médico

  • Gemfibrozil — Strukturformel Allgemeines Freiname Gemfibrozil …   Deutsch Wikipedia

  • Gemfibrozil — ГЕМФИБРОЗИЛ ( Gemfibrozil )*. 5 (2,5 Диметилфенокси) 2,2 диметилпентаноевая кислота. Синонимы: Гевилон, Dopur, Gevilon, Нipolixan, Lipigem, Lipozid, Lopid, Normolip и др. Получен в результате поиска производных клофибрата, обладающих меньшей… …   Словарь медицинских препаратов

  • gemfibrozil — noun Etymology: origin unknown Date: 1976 a drug C15H22O3 that regulates blood serum lipids and is used especially to lower the levels of triglycerides and increase the levels of HDLs in the treatment of hyperlipemia …   New Collegiate Dictionary

  • gemfibrozil — Drug that lowers plasma lipoprotein levels. Activates PPAR a …   Dictionary of molecular biology

  • gemfibrozil — noun An oral drug, one of the fibrates, used to lower lipid levels …   Wiktionary

  • gemfibrozil — An antihyperlipidemic agent. * * * gem·fi·bro·zil jem fī brə (.)zil, fib rə n a drug C15H22O3 that regulates blood serum lipids and is used esp. to lower the levels of triglycerides and increase the levels of HDLs in the treatment of… …   Medical dictionary

  • gemfibrozil — gem·fi·bro·zil …   English syllables

  • gemfibrozil — n. a drug used to lower levels of very low density lipoproteins in patients with hypertriglyceridaemia who have not responded to diet, weight reduction, or exercise (see fibrates). It is administered by mouth; side effects include diarrhoea,… …   The new mediacal dictionary

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