Guanylyl transferase

Guanylyl transferase

Guanylyl transferase enzymes transfer one molecule of guanosine triphosphate (GTP) to another molecule, releasing pyrophosphate. Many eukaryotic guanylyl transferases are capping enzymes that catalyze the formation of the 5' cap in the post-transcriptional modification of messenger RNA. Because the 5' end of the RNA molecule ends in a phosphate group, the bond formed between the RNA and the GTP molecule is an unusual 5'-5' triphosphate linkage, instead of the 3'-5' linkages between the other nucleotides that form an RNA strand. In capping enzymes, a highly conserved lysine residue serves as the catalytic residue that forms a covalent enzyme-GMP complex. Fresco LD, Buratowski S. (1994). Active site of the mRNA-capping enzyme guanylyltransferase from Saccharomyces cerevisiae: similarity to the nucleotidyl attachment motif of DNA and RNA ligases. "Proc Natl Acad Sci USA" 91(14): 6624–6628.]

The transfer RNA (tRNA) for histidine is unique among eukaryotic tRNAs in requiring the addition of a guanine nucleotide before being aminoacylated by the histidine tRNA synthetase. The yeast guanylyl transferase specific to tRNAHis is unique in being the only known non-tRNA synthetase enzyme that specifically recognizes the tRNA anticodon. Jackman JE, Phizicky EM. (2006). tRNAHis guanylyltransferase adds G–1 to the 5' end of tRNAHis by recognition of the anticodon, one of several features unexpectedly shared with tRNA synthetases. "RNA" 12:1007-1014.]

Guanylyl transferases also exist for transferring guanosine nucleotides to sugar molecules, such as mannose and fucose.

External links

* [http://www.expasy.org/enzyme/2.7.7.- EC number 2.7.7.-] - nucleotidyltransferases

References


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  • гуанилилтрансфераза — guanylyl transferase гуанилилтрансфераза (см. cap). (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

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