Cleavage stimulatory factor

Cleavage stimulatory factor

Cleavage stimulatory factor or cleavage stimulation factor (CstF or CStF) is a heterotrimeric protein of about 200 kilodaltons that is involved in the cleavage of the 3' signaling region from a newly synthesized pre-messenger RNA (mRNA) molecule. CstF is recruited by cleavage and polyadenylation specificity factor (CPSF) and assembles into a protein complex on the 3' end to promote the synthesis of a functional polyadenine tail, which results in a mature mRNA molecule ready to be exported from the cell nucleus to the cytoplasm for translation.

The amount of CstF in a cell is dependent on the phase of the cell cycle, increasing significantly during the transition from G0 phase to S phase.

References

* Lodish H, Berk A, Matsudaira P, Kaiser CA, Krieger M, Scott MP, Zipursky SL, Darnell J. (2004). "Molecular Cell Biology." WH Freeman: New York, NY. 5th ed.
* Martincic K, Campbell R, Edwalds-Gilbert G, Souan L, Lotze MT, Milcarek C. (1998). Increase in the 64-kDa subunit of the polyadenylation/cleavage stimulatory factor during the G0 to S phase transition. "Proc Natl Acad Sci USA" 95(19):11095-100.


Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать курсовую

Look at other dictionaries:

  • Cleavage stimulation factor — Cleavage stimulatory factor or cleavage stimulation factor (CstF or CStF) is a heterotrimeric protein of about 200 kilodaltons that is involved in the cleavage of the 3 signaling region from a newly synthesized pre messenger RNA (mRNA) molecule.… …   Wikipedia

  • Cleavage and polyadenylation specificity factor — (CPSF) (or Cleavage polyadenylation stimulating factor) is involved in the cleavage of the 3 signaling region from a newly synthesized pre messenger RNA (pre mRNA) molecule in the process of gene transcription. It is the first protein to bind to… …   Wikipedia

  • Cleavage factor — Cleavage factors are two closely related proteins involved in the cleavage of the 3 signaling region from a newly synthesized pre messenger RNA (mRNA) molecule in the process of gene transcription. The cleavage is the first step in adding a… …   Wikipedia

  • CSTF2 — Cleavage stimulation factor, 3 pre RNA, subunit 2, 64kDa, also known as CSTF2, is a human gene.cite web | title = Entrez Gene: CSTF2 cleavage stimulation factor, 3 pre RNA, subunit 2, 64kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene… …   Wikipedia

  • Polyadenylation — Typical structure of a mature eukaryotic mRNA Polyadenylation is the addition of a poly(A) tail to an RNA molecule. The poly(A) tail consists of multiple adenosine monophosphates; in other words, it is a stretch of RNA that has only adenine bases …   Wikipedia

  • Polynucleotide adenylyltransferase — Identifiers EC number 2.7.7.19 CAS number 9026 30 6 …   Wikipedia

  • Gastrin — In humans, gastrin is a hormone that stimulates secretion of gastric acid (HCl) by the parietal cells of the stomach, as well as aiding in gastric motility. It is released by G cells in the stomach and duodenum. Its existence was first suggested… …   Wikipedia

  • TCEA1 — Transcription elongation factor A (SII), 1, also known as TCEA1, is a human gene.cite web | title = Entrez Gene: TCEA1 transcription elongation factor A (SII), 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView… …   Wikipedia

  • endocrine system, human — ▪ anatomy Introduction  group of ductless glands (gland) that regulate body processes by secreting chemical substances called hormones (hormone). Hormones act on nearby tissues or are carried in the bloodstream to act on specific target organs… …   Universalium

  • Antithrombin — Serpin peptidase inhibitor, clade C (antithrombin), member 1 Antithrombin monomer drawn from PDB 2ANT …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”