Mouse hepatitis virus

Mouse hepatitis virus
Virus classification
Group:	Group IV ((+)ssRNA)
Order:	Nidovirales
Family:	Coronaviridae
Genus:	Coronavirus

Mouse hepatitis virus is a virus of the family Coronaviridae, genus coronavirus.

Mouse hepatitis virus (MHV) is a coronavirus that causes an epidemic murine illness with high mortality, especially among colonies of laboratory mice. Prior to the discovery of SARS-CoV, MHV had been the best-studied coronavirus both in vivo and in vitro as well as at the molecular level. Some strains of MHV cause a progressive demyelinating encephalitis in mice which has been used as a murine model for multiple sclerosis. Significant research efforts have been focused on elucidating the viral pathogenesis of these animal coronaviruses, especially by virologists interested in veterinary and zoonotic diseases.

References

• University of Illinois entry (PDF)

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