Doxapram

Doxapram
Doxapram
Systematic (IUPAC) name
1-ethyl-4- (2-morpholin-4-ylethyl)- 3,3-diphenyl-pyrrolidin-2-one
Clinical data
Pregnancy cat.  ?
Legal status  ?
Routes Intravenous
Identifiers
CAS number 309-29-5 YesY
ATC code R07AB01
PubChem CID 3156
DrugBank APRD00935
ChemSpider 3044 YesY
UNII 94F3830Q73 YesY
KEGG D07873 YesY
ChEBI CHEBI:681848 YesY
ChEMBL CHEMBL1754 YesY
Chemical data
Formula C24H30N2O2 
Mol. mass 378.507 g/mol
SMILES eMolecules & PubChem
 YesY(what is this?)  (verify)

Doxapram hydrochloride (marketed as Dopram, Stimulex or Respiram) is a respiratory stimulant. Administered intravenously, doxapram stimulates an increase in tidal volume, and respiratory rate.

Contents

Mode of action

photograph of a vial of doxapram
A vial of doxapram

Doxapram stimulates chemoreceptors in the carotid arteries, which in turn, stimulates the respiratory centre in the brain stem.

Presentation

Doxapram is a white to off-white, odorless, crystalline powder that is stable in light and air. It is soluble in water, sparingly soluble in alcohol and practically insoluble in ether. Injectable products have a pH from 3.5-5. Benzyl alcohol or chlorobutanol is added as a preservative agent in the commercially available injections.

Uses

Doxapram is used in intensive care settings to stimulate the respiratory rate in patients with respiratory failure. It may be useful for treating respiratory depression in patients who have taken excessive doses of drugs such as buprenorphine which may fail to respond adequately to treatment with naloxone.[1]

It is equally effective as pethidine in suppressing shivering after surgery.[2]

Side effects

High blood pressure, panic attacks, tachycardia (rapid heart rate), tremor, sweating and vomiting may occur. Convulsions have been reported. It cannot be used in patients with coronary heart disease, epilepsy and high blood pressure. It is also contraindicated in newborns and small children, mainly due to the presence of benzyl alcohol.

References

  1. ^ Buprenorphine Drug Data Sheet
  2. ^ Singh, P; Dimitriou, V; Mahajan, RP; Crossley, AW (1993). "Double-blind comparison between doxapram and pethidine in the treatment of postanaesthetic shivering". British journal of anaesthesia 71 (5): 685–8. doi:10.1093/bja/71.5.685. PMID 8251281. 

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Look at other dictionaries:

  • Doxapram — molécule de doxapram Général Nom IUPAC 1 ethyl 4 (2 morpholin 4 ylethyl) 3,3 diphenyl pyrrolidin 2 one No CAS …   Wikipédia en Français

  • doxapram — /dokˈsə pram/ noun A drug used as a respiratory stimulant …   Useful english dictionary

  • doxapram — n. an analeptic drug used to raise the level of consciousness in comatose patients so that they can be encouraged to cough and bring up bronchial secretions. It is administerd by mouth or injection. Possible side effects include nausea, rapid and …   Medical dictionary

  • doxapram — n. an analeptic drug used to raise the level of consciousness in patients recovering from surgery and to treat respiratory failure. It is administered intravenously; possible side effects include nausea, rapid heartbeat, dizziness, restlessness,… …   The new mediacal dictionary

  • doxapram hydrochloride — A central nervous system stimulant, advocated but infrequently used as a respiratory stimulant in anesthesia. * * * dox·a·pram hy·dro·chlo·ride (dokґsə pram) [USP] a respiratory stimulant used in the treatment of respiratory depression… …   Medical dictionary

  • clorhidrato de doxapram — Estimulante respiratorio utilizado para mejorar la función respiratoria después de la anestesia, en la depresión del sistema nervioso inducida por fármacos, y en las enfermedades pulmonares crónicas asociadas con hipercapnia aguda. Diccionario …   Diccionario médico

  • Доксапрам (Doxapram) — лекарственное вещество, стимулирующее дыхание и оказывающее на организм такое же воздействие, как никетамид. Торговое название: допрам (Dopram). Источник: Медицинский словарь …   Медицинские термины

  • 309-29-5 — Doxapram Doxapram molécule de doxapram Général Nom IUPAC 1 ethyl 4 (2 morpholin 4 ylethyl) 3,3 diphenyl pyrrolidin 2 one …   Wikipédia en Français

  • Dopram — Doxapram Doxapram molécule de doxapram Général Nom IUPAC 1 ethyl 4 (2 morpholin 4 ylethyl) 3,3 diphenyl pyrrolidin 2 one …   Wikipédia en Français

  • ДОКСАПРАМ — (doxapram) лекарственное вещество, стимулирующее дыхание и оказывающее на организм такое же воздействие, как никетамид. Торговое название: допрам (Dopram) …   Толковый словарь по медицине

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