Paragard

Paragard

The ParaGard T-380A is a copper-T IUD manufactured and marketed in the United States by Duramed Pharmaceuticals. It is the only copper-containing intrauterine device approved for use in the U.S. (a hormonal uterine device, the Mirena, is also approved). The ParaGard consists of a T-shaped polyethylene frame wound with copper wire, along with two monofilament threads to aid in removal of the IUD. The ParaGard is typically inserted and removed under local anesthesia in a gynecologist's office. The ParaGard is currently approved for 10 years use, however the newest data shows it actually remains effective for at least 12 years, and perhaps beyond, after which it should be removed and replaced if desired. The ParaGard can be used as a form of emergency contraception if inserted within three to five days after unprotected intercourse, and it can be inserted directly after childbirth or abortion.

Like all (non-hormonal) IUDs, the ParaGard prompts the release of leukocytes and prostaglandins by the endometrium. These substances are hostile to both sperm and eggs; the presence of copper increases this spermicidal effect. Although the only experimentally demonstrated effect is spermicidal/ovicidal, it is possible the IUD may rarely prevent the development of embryos. [cite web |title=Mechanisms of the Contraceptive Action of Hormonal Methods and Intrauterine Devices (IUDs) |work=Family Health International |year=2006 |url=http://www.fhi.org/en/RH/Pubs/booksReports/methodaction.htm |accessdate=2006-07-05 ] [cite web |last=Keller |first=Sarah |title=IUDs Block Fertilization |work=Network |publisher=Family Health International |year=Winter 1996, Vol. 16, No. 2 |url=http://www.fhi.org/en/RH/Pubs/Network/v16_2/nt1623.htm |accessdate=2006-07-05 ]

The ParaGard's perfect and typical use effectiveness rate is 99.4%. First year expulsion rate is 5.7%, with expulsion rates dropping off sharply after the first year. There is a higher risk of expulsion for women who have never given birth. Side effects can include heavier or longer periods, worsening cramps and may include a slightly increased risk of PID. There is anecdotal evidence that although the first few periods after insertion may be heavier and more uncomfortable than usual, this does appear to abate in most users.

The ParaGard T 380A was developed in the 1970s by the Population Council and Finishing Enterprises Inc. (FEI). The Population Council's ParaGard NDA was approved by the FDA and FEI began manufacturing it for distribution outside the United States in 1984. GynoPharma (original name GynoMed) began marketing it in the U.S. in May 1988. On August 2, 1995, Ortho-McNeil acquired GynoPharma and began marketing ParaGard in the U.S. On January 1, 2004, FEI Women's Health acquired the patent from the Population Council and U.S. marketing rights from Ortho-McNeil. On November 10, 2005, Durmaed Pharmaceuticals, a subsidiary of Barr Pharmaceuticals, acquired FEI Women's Health and ParaGard.

The original FDA approval of ParaGard in 1984 was for 4 years continuous use, this was later extended to 6 years in 1989, then 8 years in 1991, then 10 years in 1994.

External links

* [http://www.paragard.com ParaGard T 380A Intrauterine Copper Contraceptive] ]
* [http://www.paragard.com/paragard/custom_images/Package-Insert.pdf ParaGard T 380A Patient Package Insert]
* [http://archive.ddapa.com/paragard/Media/timeline.html FEI Women's Health ParaGard T 380A Timeline]

References


Wikimedia Foundation. 2010.

Игры ⚽ Поможем сделать НИР

Look at other dictionaries:

  • Paragard — Para·gard (parґəgahrd) trademark for a type of copper intrauterine device …   Medical dictionary

  • IUD with copper — This article is about non hormonally based intrauterine contraceptives. For hormonally based intrauterine contraceptives such as Mirena, see Hormonal IUD. IUD with copper Photo of a common IUD (Paragard T 380A) Background Birth co …   Wikipedia

  • Intrauterine device — Copper IUD (Paragard T 380A) Hormonal …   Wikipedia

  • Depo-Provera — is a branded progestogen only contraceptive, depot medroxyprogesterone acetate (DMPA) long acting reversible hormonal contraceptive birth control drug that is injected every 3 months. It is an aqueous suspension for depot injection of the… …   Wikipedia

  • Long Acting Reversible Contraceptive — (LARC) Devices are birth control methods that provide effective contraception for an extended period of time. In contrast, oral contraceptive pills must be taken daily to provide effective pregnancy prevention.Efficacy and CostLARC Devices have… …   Wikipedia

  • Birth control — For other uses, see Birth control (disambiguation). Birth control is an umbrella term for several techniques and methods used to prevent fertilization or to interrupt pregnancy at various stages. Birth control techniques and methods include… …   Wikipedia

  • IUD with progestogen — IntraUterine System (Mirena) Background Birth control type Intrauterine First use 1990 (Mirena currently available) 1976 (Progestasert discontinued in 2001) Failure rates (first year, Mirena) Perfect use 0.2% …   Wikipedia

  • IntraUterine System — Infobox Birth control name = IntraUterine System width = caption = bc type = Intrauterine date first use = 1990 (Mirena) 1976 (Progestasert) rate type = Failure failure measure = first year, Mirena perfect failure% = 0.2 typical failure% = ?… …   Wikipedia

  • Comparison of birth control methods — Different types of birth control methods have large differences in effectiveness, actions required of users, and side effects. Contents 1 Ease of use 2 User dependence 3 Side effects 4 Effectiveness …   Wikipedia

  • Dispositivo intrauterino — Saltar a navegación, búsqueda Para otros usos de este término, véase Diu (desambiguación). Un dispositivo intrauterino. El dispositivo intrauterino o DIU es un método anticonceptivo que consiste en la in …   Wikipedia Español

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”