Pharmacophore discovery is a means of lead discovery or lead optimization, used in
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Discovery and development of dual serotonin and norepinephrine reuptake inhibitors — Serotonin–norepinephrine reuptake inhibitors (SNRIs) are a class of antidepressant drugs used in the treatment of major depressive disorder (MDD). SNRIs are potent inhibitors of serotonin (5 Hydroxytryptamine, 5 HT) and norepinephrine (NE,… … Wikipedia
Discovery and development of TRPV1 antagonists — Chronic pain remains a recognized unmet medical need. Consequently, the search for new analgesic agents is being intensively studied by the pharmaceutical industry. The TRPV1 receptor is an ion channel that has been implicated in mediation of… … Wikipedia
Discovery and development of angiotensin receptor blockers — The angiotensin receptor blockers (ARBs), also called angiotensin (AT1) receptor antagonists or sartans, are a group of anti hypertensive drugs that act by blocking the effects of the hormone angiotensin II (Ang II) in the body, thereby lowering… … Wikipedia
Discovery and development of integrase inhibitors — The first human immunodeficiency virus (HIV) case was reported in the 1980s. Many drugs have been discovered to treat the disease but mutations in the virus and resistance to the drugs make development difficult. Integrase is a viral enzyme that… … Wikipedia
Pharmacophore — A pharmacophore was first defined by Paul Ehrlich in 1909 as a molecular framework that carries ( phoros ) the essential features responsible for a drug’s ( =pharmacon s ) biological activity (Ehrlich. Dtsch. Chem. Ges. 1909, 42: p.17). In 1977,… … Wikipedia
Discovery and development of non-nucleoside reverse-transcriptase inhibitors — Non nucleoside reverse transcriptase inhibitors (NNRTIs) are antiretroviral drugs used in the treatment of human immunodeficiency virus (HIV). NNRTIs inhibit reverse transcriptase (RT), an enzyme that controls the replication of the genetic… … Wikipedia
Discovery and development of cyclooxygenase 2 inhibitors — Cyclooxygenases are enzymes that take part in a complex biosynthetic cascade that results in the conversion of polyunsaturated fatty acids to prostaglandins and thromboxane(s).[1] Their main role is to catalyze the transformation of arachidonic… … Wikipedia
Discovery and development of triptans — Triptans is a word commonly used for a class of anti migraine drugs that are selective 5 hydroxytryptamine/serotonin1B/1D (5 HT1B/1D) agonists.[1] Migraine is a complex disease which affects about 15% of the population and can be highly disabling … Wikipedia
Drug discovery — In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which drugs are discovered and/or designed. In the past most drugs have been discovered either by identifying the active ingredient from traditional… … Wikipedia
Natural product drug discovery — This article describes the utilization of natural resources in the process of finding new drug compounds, an approach commonly referred to as natural product drug discovery . Together with synthetic chemistry, they represent complementary… … Wikipedia
