Mallory body

Mallory body
Micrograph showing a Mallory body with the characteristic twisted-rope appearance (centre of image - within a ballooning hepatocyte). H&E stain.

In histopathology, a Mallory body, Mallory-Denk body, and Mallory's hyaline, is an inclusion found in the cytoplasm of liver cells.[1]

Contents

Associated conditions

Mallory bodies are classically found in the livers of people suffering from alcoholic liver disease and were once thought to be specific for that.

They are most common in alcoholic hepatitis (prevalence of 65%) and alcoholic cirrhosis (prevalence of 51%).[2]

They are a recognized feature of Wilson's disease (25%), primary biliary cirrhosis (24%), non-alcoholic cirrhosis (24%), hepatocellular carcinoma (23%) and morbid obesity (8%), among other conditions.[2]

Appearance

Mallory bodies are highly eosinophilic and thus appear pink on H&E stain. The bodies themselves are made up of intermediate keratin filament proteins that have been ubiquinated, or bound by other proteins such as heat shock proteins, or p62.

Eponym

It is named for Frank Burr Mallory. [3]. [2]

See also

  • Ballooning degeneration - another histopathologic finding of steatohepatitis.

Additional images

References

  1. ^ "Cell Injury". http://library.med.utah.edu/WebPath/CINJHTML/CINJ033.html. 
  2. ^ a b c Jensen, K; Gluud, C (Oct 1994). "The Mallory body: morphological, clinical and experimental studies (Part 1 of a literature survey).". Hepatology 20 (4 Pt 1): 1061–77. doi:10.1002/hep.1840200440. PMID 7927209. 
  3. ^ Template:AKADrewParlin
v · d · eEponymous medical signs for digestive system and abdomen
Digestive system
Abdominopelvic
Howship-Romberg sign · Hannington-Kiff sign
Other
Abdominal · general

spleen/LUQ: Ballance's sign · Traube's sign · Castell's sign

hemorrhage: Cullen's sign · Grey Turner's sign

M: DIG

anat(t, g, p)/phys/devp/enzy

noco/cong/tumr, sysi/epon

proc, drug(A2A/2B/3/4/5/6/7/14/16), blte

Wikimedia Foundation. 2010.

Игры ⚽ Нужно решить контрольную?

Look at other dictionaries:

  • Mallory — For other uses, see Mallory (disambiguation). Contents 1 Notable people with the surname 2 Fictional characters with the surname …   Wikipedia

  • Mallory–Neely House — Mallory Neely House U.S. Historic district Contributing property …   Wikipedia

  • Mallory Mill — U.S. National Register of Historic Places …   Wikipedia

  • Mallory Hotel — U.S. National Register of Historic Places …   Wikipedia

  • Mallory and Irvine — [Mallory and Irvine] two English ↑climbers, George Mallory (1886–1924) and Andrew Irvine (1902–1924), who died while attempting to reach the top of Mount Everest. When Mallory was asked why he wanted to climb Everest, his famous reply was… …   Useful english dictionary

  • Mallory — Mallory, George (1887 1924) a British mountain climber, who died while attempting to climb Mount Everest. In 1999 his body was found 2,000 feet from the top of the mountain. Some people believe that he and another climber, Andrew Irvine, were the …   Dictionary of contemporary English

  • Mallory and Irvine Research Expedition — The goal of the Mallory and Irvine Research Expedition of 1999 was to discover evidence of whether George Mallory and Andrew Irvine had been the first to summit Mt. Everest in their ill fated attempt of 8–9 June 1924. The expedition was organized …   Wikipedia

  • Mallory, George — ▪ British explorer and mountaineer in full  George Herbert Leigh Mallory  born June 18, 1886, Mobberley, Cheshire, England died June 8, 1924, North Face of Mount Everest, Tibet [now in China]       British explorer and mountaineer… …   Universalium

  • body — 1. The head, neck, trunk, and extremities. The human b., consisting of head (caput), neck (collum), trunk (truncus), and limbs (membra). 2. The material part of a human, as distinguished from the …   Medical dictionary

  • Mallory and Irvine — two English climbers, George Mallory (1886–1924) and Andrew Irvine (1902–1924), who died while attempting to reach the top of Mount Everest. When Mallory was asked why he wanted to climb Everest, his famous reply was ‘Because it is there’. His… …   Universalium

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”