PelB leader sequence

PelB leader sequence

The pelB leader sequence is a sequence of amino acids which when attached to a protein, directs the protein to the periplasmic membrane of "E. coli", where the sequence is removed by pelB peptidase. It is used to direct coat protein-antigen fusions to the cell surface for construction of engineered bacteriophage for the purpose of phage display.


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  • pelB — The 18 residue N terminal leader sequence of pelB is commonly used in various vector constructs. The gene from which it comes, pelB, codes for pectin lyase B, one of the many virulence factors of Erwinia chrysanthemi, pectinases that degrade cell …   Dictionary of molecular biology

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