Nilutamide

Nilutamide

Systematic (IUPAC) name
5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl] imidazolidine-2,4-dione
Clinical data
Trade names	Nilandron
AHFS/Drugs.com	monograph
MedlinePlus	a697044
Pregnancy cat.	?
Legal status	pr
Routes	oral
Pharmacokinetic data
Half-life	38.0 to 59.1 hours
Identifiers
CAS number	63612-50-0 Y
ATC code	L02BB02
PubChem	CID 4493
DrugBank	APRD00150
ChemSpider	4337 Y
UNII	51G6I8B902 Y
KEGG	D00965 Y
ChEBI	CHEBI:7573 N
ChEMBL	CHEMBL1274 Y
Chemical data
Formula	C12H10F3N3O4
Mol. mass	317.221 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C12H10F3N3O4/c1-11(2)9(19)17(10(20)16-11)6-3-4-8(18(21)22)7(5-6)12(13,14)15/h3-5H,1-2H3,(H,16,20) Y Key:XWXYUMMDTVBTOU-UHFFFAOYSA-N Y
N(what is this?)  (verify)

Nilutamide is an antiandrogen medication used in the treatment of advanced stage prostate cancer. Nilutamide blocks the androgen receptor, preventing its interaction with testosterone. Because most prostate cancer cells rely on the stimulation of the androgen receptor for growth and survival, nilutamide can prolong life in men with prostate cancer. Nilutamide is marketed under the name Nilandron in the United States and under the name Anandron in Canada.

References

• Kassouf W, Tanguay S, Aprikian AG. Nilutamide as second line hormone therapy for prostate cancer after androgen ablation fails. J. Urol. 2003 May;169(5):1742-4. PMID 12686822
• Moguilewsky M, Bertagna C, Hucher M. (1987) Pharmacological and clinical studies of the antiandrogen Anandron (nilutamide). J Steroid Biochem. (4-6):871-5.
• Hsieh AC, Ryan CJ. (2008) Novel concepts in androgen receptor blockade. Cancer J. 14(1):11-14.

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This drug article relating to the genito-urinary system is a stub. You can help Wikipedia by expanding it.v · Categories: Drugs acting on the genito-urinary system Andrology Nitrobenzenes Organofluorides Hydantoins Antineoplastic and immunomodulating drug stubs Genito-urinary system drug stubs Wikimedia Foundation. 2010. Игры ⚽ Поможем решить контрольную работу Alexander Fraser, 14th Lord Saltoun Youth system Look at other dictionaries: nilutamide — ni·lu·ta·mide (ni looґtə mīd) a nonsteroidal antiandrogen used as an antineoplastic, in combination with measures to lower testosterone levels such as bilateral orchiectomy, in treatment of prostatic carcinoma; administered orally …   Medical dictionary nilutamide — A drug that blocks the effects of male hormones in the body. It belongs to the family of drugs called antiandrogens …   English dictionary of cancer terms Discovery and development of antiandrogens — In the 1960s, the first antiandrogen, or androgen antagonist, was discovered. Antiandrogens antagonise the androgen receptor (AR) and thereby block the biological effects of testosterone and dihydrotestosterone (DHT). Antiandrogens are important… …   Wikipedia ANTIHORMONES — La notion d’antihormone s’applique aujourd’hui aux molécules capables d’inhiber de façon compétitive la formation du complexe hormone récepteur. Sa définition première, désignant toute substance capable de s’opposer aux effets résultant de… …   Encyclopédie Universelle Testosterone — For the film, see Testosterone (film). Testosterone Systematic (IUPAC) name …   Wikipedia Prostate cancer — is a disease in which cancer develops in the prostate, a gland in the male reproductive system. It occurs when cells of the prostate mutate and begin to multiply out of control. These cells may spread (metastasize) from the prostate to other… …   Wikipedia Antiandrogen — An antiandrogen, or androgen antagonist, is any of a group of hormone receptor antagonist compounds that are capable of preventing or inhibiting the biologic effects of androgens, male sex hormones, on normally responsive tissues in the body (see …   Wikipedia Androgen — Androgen, also called androgenic hormone or testoid, is the generic term for any natural or synthetic compound, usually a steroid hormone, that stimulates or controls the development and maintenance of male characteristics in vertebrates by… …   Wikipedia Methyltestosterone — Systematic (IUPAC) name 17b hydroxy 17a methylandrost 4 ene 3 one Clinical data Trade names Virilo …   Wikipedia Spironolactone — Systematic (IUPAC) name 7α Acetylthio 3 oxo 17α pregn 4 ene 21,17 carbolactone OR (1 S,2R,2 R,9 R,10 R,11 S,15 S) 9 (acetylsulfanyl) 2 ,15 dimethylspiro[oxolane 2,14 tetracyclo[8.7.0.0 …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”