Cilastatin

Cilastatin
Cilastatin
Systematic (IUPAC) name
(Z)-7-[(2R)-2-amino-3-hydroxy-3-oxopropyl]sulfanyl-2-{[(1S)-
2,2-dimethylcyclopropanecarbonyl]amino}hept-2-enoic acid
Clinical data
AHFS/Drugs.com International Drug Names
MedlinePlus a686013
Pregnancy cat.  ?
Legal status  ?
Identifiers
CAS number 82009-34-5 YesY
ATC code  ?
PubChem CID 5280454
DrugBank EXPT00918
ChemSpider 4940183 YesY
UNII 141A6AMN38 YesY
KEGG D07698 YesY
ChEBI CHEBI:3697 YesY
ChEMBL CHEMBL766 YesY
Chemical data
Formula C16H26N2O5S 
Mol. mass 358.454 g/mol
SMILES eMolecules & PubChem
 N(what is this?)  (verify)

Cilastatin is a chemical compound which inhibits the human enzyme dehydropeptidase.[1]

Dehydropeptidase is found in the kidney and is responsible for degrading the antibiotic imipenem. Cilastatin is therefore combined intravenously with imipenem in order to protect it from dehydropeptidase and prolong its antibacterial effect. However, cilastatin itself does not have antibiotic activity.

Another carbapenem, meropenem is resistant to dehydropeptidase; therefore, it can be given without cilastatin.

References

See also


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