Olke C. Uhlenbeck

O. C. Uhlenbeck
Residence	USA
Citizenship	American
Fields	Biochemistry Biophysics
Institutions	University of Illinois University of Colorado Northwestern University
Alma mater	University of Michigan Harvard University
Doctoral advisor	Paul Doty
Known for	RNA synthesis from synthetic templates, RNA protein interactions, RNA Biochemistry
Notes His father was the famous Physicist George Eugene Uhlenbeck.

Olke C. Uhlenbeck is a biochemist presently at Northwestern University.^[1] He was elected to the United States National Academy of Sciences in 1993 ^[2] and has published over 200 peer reviewed articles.^[3] His research group has led to many breakthroughs in RNA biochemistry, most notably the enzymatic synthesis of RNAs from synthetic DNA templates using T7 RNA polymerase.^[4]

Early Contributions

As a graduate student in Paul Doty's lab, Olke showed that the anticodon of tRNA was accessible to hybridization to oligonucleotides.^[5] Later, as a postdoc in Ignacio Tinoco, Jr.'s lab he helped define an original model for RNA secondary structure prediction.^[6]

Contributions from the Uhlenbeck Lab

Olke is a longstanding contributor to RNA biochemistry. His group has shown many important findings as well as developed important tools for RNA biochemists. Notable contributions include:

• Walker, G. C.; Uhlenbeck, OC; Bedows, E; Gumport, RI (1975). "T4-Induced RNA Ligase Joins Single-Stranded Oligoribonucleotides". Proceedings of the National Academy of Sciences 72 (1): 122–6. doi:10.1073/pnas.72.1.122. PMC 432253. PMID 1090929. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=432253. 
• England, Thomas E.; Uhlenbeck, Olke C. (1978). "3′-Terminal labelling of RNA with T4 RNA ligase". Nature 275 (5680): 560–1. doi:10.1038/275560a0. PMID 692735. 
• Milligan, John F.; Groebe, Duncan R.; Witherell, Gary W.; Uhlenbeck, Olke C. (1987). "Oligoribonucleotide synthesis using T7 RNA polymerase and synthetic DNA templates". Nucleic Acids Research 15 (21): 8783–98. doi:10.1093/nar/15.21.8783. PMC 306405. PMID 3684574. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=306405. 
• Milligan, John F.; Groebe, Duncan R.; Witherell, Gary W.; Uhlenbeck, Olke C. (1987). "Oligoribonucleotide synthesis using T7 RNA polymerase and synthetic DNA templates". Nucleic Acids Research 15 (21): 8783–98. doi:10.1093/nar/15.21.8783. PMC 306405. PMID 3684574. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=306405. 
• Hertel, Klemens J.; Herschlag, Daniel; Uhlenbeck, Olke C. (1994). "A Kinetic and Thermodynamic Framework for the Hammerhead Ribozyme Reaction". Biochemistry 33 (11): 3374–85. doi:10.1021/bi00177a031. PMID 8136375. 
• Johansson, H. E. (1998). "A thermodynamic analysis of the sequence-specific binding of RNA by bacteriophage MS2 coat protein". Proceedings of the National Academy of Sciences 95: 9244–9. doi:10.1073/pnas.95.16.9244. 
• Sampson, J. R. (1988). "Biochemical and Physical Characterization of an Unmodified Yeast Phenylalanine Transfer RNA Transcribed in vitro". Proceedings of the National Academy of Sciences 85: 1033–7. doi:10.1073/pnas.85.4.1033. JSTOR 30928. 
• Sampson, JR; Direnzo, A.; Behlen, L.; Uhlenbeck, O. (1989). "Nucleotides in yeast tRNAPhe required for the specific recognition by its cognate synthetase". Science 243 (4896): 1363–6. doi:10.1126/science.2646717. PMID 2646717. 
• Lariviere, F. J.; Wolfson, AD; Uhlenbeck, OC (2001). "Uniform Binding of Aminoacyl-tRNAs to Elongation Factor Tu by Thermodynamic Compensation". Science 294 (5540): 165–8. doi:10.1126/science.1064242. PMID 11588263. 

See also

List of RNA biologists

References

1. ^ "Northwestern University Department of Molecular Biosciences The Uhlenbeck Lab Home". Biochem.northwestern.edu. http://www.biochem.northwestern.edu/uhlenbeck/index.htm. Retrieved 2011-03-02. 
2. ^ "National Academy of Sciences:". Nasonline.org. http://www.nasonline.org/site/Dir?sid=1011&view=basic&pg=srch. Retrieved 2011-03-02. ^{[not in citation given]}
3. ^ http://www.ncbi.nlm.nih.gov/pubmed?term=%22Uhlenbeck%20OC%22%5BAuthor%5D
4. ^ Milligan, John F.; Groebe, Duncan R.; Witherell, Gary W.; Uhlenbeck, Olke C. (1987). "Oligoribonucleotide synthesis using T7 RNA polymerase and synthetic DNA templates". Nucleic Acids Research 15 (21): 8783–98. doi:10.1093/nar/15.21.8783. PMC 306405. PMID 3684574. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=306405. ^{[non-primary source needed]}
5. ^ Uhlenbeck, Olke C.; Baller, Julie; Doty, Paul (1970). "Complementary Oligonucleotide Binding to the Anticodon Loop of fMet-transfer RNA". Nature 225 (5232): 508–10. doi:10.1038/225508a0. PMID 5411856. ^{[non-primary source needed]}
6. ^ Tinoco, Ignacio; Uhlenbeck, Olke C.; Levine, Mark D. (1971). "Estimation of Secondary Structure in Ribonucleic Acids". Nature 230 (5293): 362–7. doi:10.1038/230362a0. PMID 4927725. ^{[non-primary source needed]}

Persondata
Name	Uhlenbeck, Olke C.
Alternative names	Uhlenbeck, Olke
Short description	RNA Biochemist
Date of birth
Place of birth
Date of death
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