- Nitroreductase
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Nitroreductase Identifiers Symbol Nitroreductase Pfam PF00881 InterPro IPR000415 Available protein structures: Pfam structures PDB RCSB PDB; PDBe PDBsum structure summary Nitroreductases are a family of evolutionarily related proteins involved in the reduction nitrogen containing compounds including those containing the nitro functional group. Members of this family utilise FMN as a cofactor and are often found to be homodimers.[1][2]
Members of this family include oxygen-insensitive NAD(P)H nitroreductase (FMN-dependent nitroreductase) (6,7-dihydropteridine reductase) (EC 1.5.1.34) and NADH dehydrogenase (EC 1.6.99.3). A number of these proteins are described as oxidoreductases. They are primarily found in bacterial lineages though a number of eukaryotic homologs have been identified: C. elegans P34273, D. melanogaster Q8T3Q0, Q9VTE7, mouse Q9DCX8 and human O75989. This protein is not found in photosynthetic eukaryotes. The sequences containing this entry in photosynthetic organisms are possible false positives.
Subfamilies
Human proteins containing this domain
IYD;
References
- ^ Hecht HJ, Erdmann H, Park HJ, Sprinzl M, Schmid RD (December 1995). "Crystal structure of NADH oxidase from Thermus thermophilus". Nat. Struct. Biol. 2 (12): 1109–14. doi:10.1038/nsb1295-1109. PMID 8846223.
- ^ de Oliveira IM, Henriques JA, Bonatto D (April 2007). "In silico identification of a new group of specific bacterial and fungal nitroreductases-like proteins". Biochem. Biophys. Res. Commun. 355 (4): 919–25. doi:10.1016/j.bbrc.2007.02.049. PMID 17331467.
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