NLRC5

NLRC5
NLR family, CARD domain containing 5
Identifiers
Symbols NLRC5; CLR16.1; FLJ21709; FLJ39711; NOD27; NOD4
External IDs OMIM613537 MGI3612191 HomoloGene88935 GeneCards: NLRC5 Gene
Orthologs
Species Human Mouse
Entrez 84166 434341
Ensembl ENSG00000140853 ENSMUSG00000031773
UniProt Q86WI3 Q3U1H4
RefSeq (mRNA) NM_032206 NM_001033207
RefSeq (protein) NP_115582 NP_001028379
Location (UCSC) Chr 16:
57.02 – 57.12 Mb
Chr 8:
97 – 97.03 Mb
PubMed search [1] [2]

NLRC5, short for NOD-like receptor family CARD domain containing 5, is an intracellular protein that plays a role in the immune system. NLRC5 is a pattern recognition receptor implicated in innate immunity to viruses potentially by regulating interferon activity.[1][2][3]

In humans, the NLRC5 protein is encoded by the NLRC5 gene.[4] It has also been called NOD27, NOD4, and CLR16.1.

References

  1. ^ Neerincx A, Lautz K, Menning M, et al. (June 2010). "A role for the human NLR family member NLRC5 in antiviral responses". J Biol Chem 285 (34): 26223–32. doi:10.1074/jbc.M110.109736. PMC 2924034. PMID 20538593. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2924034. 
  2. ^ Cui J, Zhu L, Xia X, et al. (April 2010). "NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways". Cell 141 (3): 483–96. doi:10.1016/j.cell.2010.03.040. PMID 20434986. 
  3. ^ Kuenzel S, Till A, Winkler M, et al. (February 2010). "The nucleotide-binding oligomerization domain-like receptor NLRC5 is involved in IFN-dependent antiviral immune responses". J. Immunol. 184 (4): 1990–2000. doi:10.4049/jimmunol.0900557. PMID 20061403. 
  4. ^ Dowds TA, Masumoto J, Chen FF, Ogura Y, Inohara N, Núñez G (March 2003). "Regulation of cryopyrin/Pypaf1 signaling by pyrin, the familial Mediterranean fever gene product". Biochem. Biophys. Res. Commun. 302 (3): 575–80. doi:10.1016/S0006-291X(03)00221-3. PMID 12615073. 

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  • NAIP — Обозначения Символы NAIP; BIRC1, NLRB1 Entrez Gene …   Википедия

  • NOD2 — Nucleotide binding oligomerization domain containing 2 Identifiers Symbols NOD2; ACUG; BLAU; CARD15; CD; CLR16.3; IBD1; NLRC2; NOD2B; PSORAS1 External IDs …   Wikipedia

  • NOD1 — Nucleotide binding oligomerization domain containing 1 PDB rendering based on 2b1w …   Wikipedia

  • NLRP1 — NLR family, pyrin domain containing 1 Rendering of NLRP1 from PDB 1PN5 …   Wikipedia

  • NLRC4 — NLR family, CARD domain containing 4 Identifiers Symbols NLRC4; CARD12; CLAN; CLAN1; CLANA; CLANB; CLANC; CLAND; CLR2.1; IPAF External IDs …   Wikipedia

  • NLRP2 — NLR family, pyrin domain containing 2 Identifiers Symbols NLRP2; CLR19.9; FLJ20510; NALP2; NBS1; PAN1; PYPAF2 External IDs …   Wikipedia

  • NLRP7 — NLR family, pyrin domain containing 7 Identifiers Symbols NLRP7; CLR19.4; FLJ94610; HYDM; MGC126470; MGC126471; NALP7; NOD12; PAN7; PYPAF3 External IDs …   Wikipedia

  • NLRP12 — NLR family, pyrin domain containing 12 Identifiers Symbols NLRP12; CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO; RNO2 External IDs …   Wikipedia

  • NLRP4 — NLR family, pyrin domain containing 4 Identifiers Symbols NLRP4; CLR19.5; CT58; FLJ32126; NALP4; PAN2; PYPAF4; RNH2 External IDs …   Wikipedia

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