NKX6-1

NK6 homeobox 1
Identifiers
Symbols	NKX6-1; NKX6.1; NKX6A
External IDs	OMIM: 602563 MGI: 1206039 HomoloGene: 4495 GeneCards: NKX6-1 Gene
Gene Ontology Molecular function • chromatin binding • sequence-specific DNA binding Cellular component • nucleus • intracellular part Biological process • negative regulation of transcription from RNA polymerase II promoter • smoothened signaling pathway • multicellular organismal development • cell proliferation • organ morphogenesis • regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification • regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification • neurogenesis • pancreas development • endocrine pancreas development • positive regulation of insulin secretion • response to nicotine • response to drug • positive regulation of neuron differentiation • negative regulation of glial cell differentiation • positive regulation of glial cell differentiation • positive regulation of transcription from RNA polymerase II promoter • oligodendrocyte differentiation • positive regulation of sequence-specific DNA binding transcription factor activity • detection of glucose • cellular response to cytokine stimulus • cellular response to peptide hormone stimulus • type B pancreatic cell maturation • positive regulation of type B pancreatic cell development Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4825	18096
Ensembl	ENSG00000163623	ENSMUSG00000035187
UniProt	P78426	Q99MA9
RefSeq (mRNA)	NM_006168	NM_144955.2
RefSeq (protein)	NP_006159	NP_659204.1
Location (UCSC)	Chr 4: 85.41 – 85.42 Mb	Chr 5: 102.09 – 102.09 Mb
PubMed search	[1]	[2]

Homeobox protein Nkx-6.1 is a protein that in humans is encoded by the NKX6-1 gene.^[1][2]

Function

In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target genes.^[2]

References

1. ^ Inoue H, Rudnick A, German MS, Veile R, Donis-Keller H, Permutt MA (March 1997). "Isolation, characterization, and chromosomal mapping of the human Nkx6.1 gene (NKX6A), a new pancreatic islet homeobox gene". Genomics 40 (2): 367–70. doi:10.1006/geno.1996.4568. PMID 9119408. 
2. ^ ^{a b} "Entrez Gene: NK6 homeobox 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4825. 

Further reading

• Schisler JC, Fueger PT, Babu DA, et al. (2008). "Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1.". Mol. Cell. Biol. 28 (10): 3465–76. doi:10.1128/MCB.01791-07. PMID 18347054. 
• Hori Y, Gu X, Xie X, Kim SK (2005). "Differentiation of insulin-producing cells from human neural progenitor cells.". PLoS Med. 2 (4): e103. doi:10.1371/journal.pmed.0020103. PMC 1087208. PMID 15839736. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1087208. 
• Jørgensen MC, Vestergírd Petersen H, Ericson J, et al. (1999). "Cloning and DNA-binding properties of the rat pancreatic beta-cell-specific factor Nkx6.1.". FEBS Lett. 461 (3): 287–94. doi:10.1016/S0014-5793(99)01436-2. PMID 10567713. 
• Iype T, Taylor DG, Ziesmann SM, et al. (2004). "The transcriptional repressor Nkx6.1 also functions as a deoxyribonucleic acid context-dependent transcriptional activator during pancreatic beta-cell differentiation: evidence for feedback activation of the nkx6.1 gene by Nkx6.1.". Mol. Endocrinol. 18 (6): 1363–75. doi:10.1210/me.2004-0006. PMID 15056733. 
• Yokoi N, Kanamori M, Horikawa Y, et al. (2006). "Association studies of variants in the genes involved in pancreatic beta-cell function in type 2 diabetes in Japanese subjects.". Diabetes 55 (8): 2379–86. doi:10.2337/db05-1203. PMID 16873704. 
• Zhu S, Xia HH, Yang Y, et al. (2009). "Alterations of gastric homeoprotein expression in Helicobacter pylori infection, incisural antralisation, and intestinal metaplasia.". Dig. Dis. Sci. 54 (5): 996–1002. doi:10.1007/s10620-008-0459-8. PMID 18754095. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.