dnaC

dnaC
DNA replication gene dnaC
Identifiers
Symbol dnaC
Entrez 948864
UniProt P0AEF0
Other data

dnaC is a bacterial gene that codes for protein DnaC. DnaC, also known as the helicase loader, is a regulator of DnaB.[1] DnaC forms a complex with DnaB, thus enabling DnaB to perform its functions in bacterial DNA replication.[2] This interaction of DnaC with DnaB requires the hydrolysis of ATP.[3]

References

  1. ^ Fang, L, Davey, MJ, O'Donnell M (October 1999). "Replisome assembly at oriC, the replication origin of E. coli, reveals an explanation for initiation sites outside an origin". Mole. Cell. 4 (4): 541–53. doi:10.1016/S1097-2765(00)80205-1. PMID 10549286. 
  2. ^ Wahle E, Lasken RS, Kornberg A (February 1989). "The dnaB-dnaC replication protein complex of Escherichia coli. II. Role of the complex in mobilizing dnaB functions". J. Biol. Chem. 264 (5): 2469–75. PMID 2536713. http://www.jbc.org/cgi/content/abstract/264/5/2469. 
  3. ^ Kobori JA, Kornberg A (November 1982). "The Escherichia coli dnaC gene product. III. Properties of the dnaB-dnaC protein complex". J. Biol. Chem. 257 (22): 13770–5. PMID 6292205. http://www.jbc.org/cgi/content/abstract/257/22/13770. 

External links

Replication
Prokaryotic
(elongation)

Replication factor C (RFC1) · Flap endonuclease (FEN1) · Topoisomerase · Replication protein A (RPA1)

Eukaryotic DNA polymerase: delta (POLD1, POLD2, POLD3, POLD4)

DNA clamp (PCNA)
Both
Movement: Processivity · DNA ligase
Termination see also DNA replication and repair-deficiency disorder
B bsyn: dna (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°)

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  • DnaC — is a bacterial protein. It is a regulator of DnaB. DnaC forms a complex with DnaB, thus enabling DnaB to perform its functions in bacterial DNA replication. [ E Wahle, RS Lasken and A Kornberg [http://www.jbc.org/cgi/content/abstract/264/5/2469… …   Wikipedia

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  • dnaA — Chromosomal replication initiator protein dnaA Identifiers Symbol dnaA Entrez 948217 UniProt …   Wikipedia

  • DnaA — is a replication initiation factor which promotes the unwinding or denaturation of DNA at oriC (around 240bp in Escherichia coli ), during DNA replication in prokaryotes. The formation of the oriC/DnaA complex and DNA unwinding requires ATP… …   Wikipedia

  • холодочувствительная мутация — cold sensitive mutation холодочувствительная мутация. Мутация, нарушающая функционирование продукта гена при пониженной температуре, например, мутация в гене dnaC E.coli, обусловливающая нарушение инициации репликации ДНК; при одновременном… …   Молекулярная биология и генетика. Толковый словарь.

  • dnaB helicase — Replicative DNA helicase Identifiers Symbol dnaB Entrez 948555 UniProt …   Wikipedia

  • холодочувствительная мутация — Мутация, нарушающая функционирование продукта гена при пониженной температуре, например, мутация в гене dnaC E.coli, обусловливающая нарушение инициации репликации ДНК; при одновременном наличии с температурочувствительной мутацией в гене dnaA… …   Справочник технического переводчика

  • DnaB helicase — is an enzyme in bacteria which opens the replication fork during DNA replication. Initially when DnaB binds to DnaA, it is associated with DnaC, a negative regulator. After DnaC dissociates, DnaB binds DnaG.In eukaryotes, helicase function is… …   Wikipedia

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