dGTPase

dGTPase
dGTPase
Identifiers
EC number 3.1.5.1
CAS number 9025-63-2
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a dGTPase (EC 3.1.5.1) is an enzyme that catalyzes the chemical reaction

dGTP + H2O \rightleftharpoons deoxyguanosine + triphosphate

Thus, the two substrates of this enzyme are dGTP and H2O, whereas its two products are deoxyguanosine and triphosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on triphosphoric monoester bonds. The systematic name of this enzyme class is dGTP triphosphohydrolase. Other names in common use include deoxy-GTPase, deoxyguanosine 5-triphosphate triphosphohydrolase, deoxyguanosine triphosphatase, and deoxyguanosine triphosphate triphosphohydrolase. This enzyme participates in purine metabolism.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1HA3, 2C77, 2C78, and 2DQB.

References

  • KORNBERG SR, LEHMAN IR, BESSMAN MJ, SIMMS ES, KORNBERG A (1958). "Enzymatic cleavage of deoxyguanosine triphosphate to deoxyguanosine and tripolyphosphate". J. Biol. Chem. 233 (1): 159–62. PMID 13563461. 


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