Derlin-1

Derlin-1
Der1-like domain family, member 1
Identifiers
Symbols DERL1; DER-1; DER1; FLJ13784; FLJ42092; MGC3067; PRO2577
External IDs OMIM608813 MGI1915069 HomoloGene11483 GeneCards: DERL1 Gene
RNA expression pattern
PBB GE DERL1 218172 s at tn.png
PBB GE DERL1 219402 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 79139 67819
Ensembl ENSG00000136986 ENSMUSG00000022365
UniProt Q9BUN8 Q3UGB8
RefSeq (mRNA) NM_001134671.1 NM_024207.4
RefSeq (protein) NP_001128143.1 NP_077169.1
Location (UCSC) Chr 8:
124.03 – 124.05 Mb
Chr 15:
57.7 – 57.72 Mb
PubMed search [1] [2]

Derlin-1 also known as degradation in endoplasmic reticulum protein 1 is a protein that in humans is encoded by the DERL1 gene [1][2][3]. It is a member of the rhomboid-like clan of polytopic membrane proteins.

Contents

Function

Derlin-1 is part of a complex (that includes VIMP, SEL1, HRD1, and HERP) that mediates endoplasmic-reticulum-associated degradation (ERAD) that detects misfolded proteins in the endoplasmic reticulum and targets them for destruction.[4]

Clinical significance

Derlin 1 (DERL1) is up-regulated in metastatic canine mammary tumors as part of the unfolded protein response.[5][6][7]

See also

References

  1. ^ Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (Oct 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=403697. 
  2. ^ Lilley BN, Ploegh HL (Jun 2004). "A membrane protein required for dislocation of misfolded proteins from the ER". Nature 429 (6994): 834–40. doi:10.1038/nature02592. PMID 15215855. 
  3. ^ "Entrez Gene: DERL1 Der1-like domain family, member 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79139. 
  4. ^ Schaheen B, Dang H, Fares H (July 2009). "Derlin-dependent accumulation of integral membrane proteins at cell surfaces". J. Cell. Sci. 122 (Pt 13): 2228–39. doi:10.1242/jcs.048892. PMID 19509052. 
  5. ^ Klopfleisch R, Klose P, Gruber AD. (2010). "The combined expression pattern of BMP2, LTBP4, and DERL1 discriminates malignant from benign canine mammary tumors.". Veterinary Pathology. 47 (3): 446–54. doi:10.1177/0300985810363904. PMID 20375427. 
  6. ^ Klopfleisch R, Schütze M, Linzmann H, Brunnberg L, Gruber AD. (2010). "Increased Derlin-1 expression in metastases of canine mammary adenocarcinomas.". J Comp Pathol 142 (1): 79–83. PMID 19632687. 
  7. ^ Klopfleisch R, Gruber AD. (2009). "Derlin-1 and stanniocalcin-1 are differentially regulated in metastasizing canine mammary adenocarcinomas.". J Comp Pathol. 141 (2): 113–120. PMID 19515379. 

Further reading



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