- McN5652
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McN5652 rel-(6R,10bS)-6-[4-(Methylsulfanyl)phenyl]-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinolineOther namestrans-McN-5652Identifiers CAS number 96795-89-0 (±)-trans PubChem 6336338 ChemSpider 4891622 Jmol-3D images Image 1 - S(c1ccc(cc1)[C@@H]4c2c(cccc2)[C@H]3N(CCC3)C4)C
- InChI=1S/C19H21NS/c1-21-15-10-8-14(9-11-15)18-13-20-12-4-7-19(20)17-6-3-2-5-16(17)18/h2-3,5-6,8-11,18-19H,4,7,12-13H2,1H3/t18-,19+/m1/s1
Key: YVKDUIAAPBKHMJ-MOPGFXCFSA-N
InChI=1/C19H21NS/c1-21-15-10-8-14(9-11-15)18-13-20-12-4-7-19(20)17-6-3-2-5-16(17)18/h2-3,5-6,8-11,18-19H,4,7,12-13H2,1H3/t18-,19+/m1/s1
Key: YVKDUIAAPBKHMJ-MOPGFXCFBW
Properties Molecular formula C19H21NS Molar mass 295.44 g mol−1 (verify) (what is: / ?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)Infobox references McN5652 is a molecule that can be radiolabeled and then used as a radioligand in positron emission tomography (PET) studies. The [11C]-(+)-McN5652 enantiomer binds to the serotonin transporter.[1]
The radioligand is used for molecular neuroimaging, but also for imaging of the lungs.[2]
It was developed by Johnson & Johnson's McNeil Laboratories.
See also
References
- ^ M. Suehiro, U. Scheffel, H. T. Ravert, R. F. Dannals & H. N. Jr Wagner (1993). "[11C](+)McN5652 as a radiotracer for imaging serotonin uptake sites with PET". Life Sciences 53 (11): 883–882. doi:10.1016/0024-3205(93)90440-E. PMID 8366755.
- ^ Akihiro Takano, Hiroshi Ito, Yasuhiko Sudo, Makoto Inoue, Tetsuya Ichimiya, Fumihiko Yasuno, Kazutoshi Suzuki & Tetsuya Suhara (August 2007). "Effects of smoking on the lung accumulation of [11C]McN5652". Annals of Nuclear Medicine 21 (6): 349–344. doi:10.1007/s12149-007-0031-1. PMID 17705015.
Categories:- Radiopharmaceuticals
- Neuroimaging
- Johnson & Johnson
- Thioethers
- Neuroscience stubs
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