HLA-B39

Alleles

Disease

B39 is suggested as a factor in Takayasu's arteritis and gallstones in Mexico.cite journal |author=Méndez-Sánchez N, King-Martínez AC, Ramos MH, Pichardo-Bahena R, Uribe M |title=The Amerindian's genes in the Mexican population are associated with development of gallstone disease |journal=Am. J. Gastroenterol. |volume=99 |issue=11 |pages=2166–70 |year=2004 |month=November |pmid=15554998 |doi=10.1111/j.1572-0241.2004.40159.x |url=] Osteoarticular complications of
brucellosis appear to be associated with B39.cite journal |author=Bravo MJ, Colmenero Jde D, Alonso A, Caballero A |title=HLA-B*39 allele confers susceptibility to osteoarticular complications in human brucellosis |journal=J. Rheumatol. |volume=30 |issue=5 |pages=1051–3 |year=2003 |month=May |pmid=12734905 |doi= |url=] An association with spondylarthropathies cite journal |author=Sobao Y, Tsuchiya N, Takiguchi M, Tokunaga K |title=Overlapping peptide-binding specificities of HLA-B27 and B39: evidence for a role of peptide supermotif in the pathogenesis of spondylarthropathies |journal=Arthritis Rheum. |volume=42 |issue=1 |pages=175–81 |year=1999 |month=January |pmid=9920028 |doi=10.1002/1529-0131(199901)42:1<175::AID-ANR21>3.0.CO;2-7 |url=] cite journal |author=Alvarez I, López de Castro JA |title=HLA-B27 and immunogenetics of spondyloarthropathies |journal=Curr Opin Rheumatol |volume=12 |issue=4 |pages=248–53 |year=2000 |month=July |pmid=10910175 |doi= |url=http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=1040-8711&volume=12&issue=4&spage=248] and psoriatic arthritiscite journal |author=Eastmond CJ |title=Psoriatic arthritis. Genetics and HLA antigens |journal=Baillieres Clin Rheumatol |volume=8 |issue=2 |pages=263–76 |year=1994 |month=May |pmid=8076387 |doi= |url=] cite journal |author=Gladman DD, Farewell VT |title=The role of HLA antigens as indicators of disease progression in psoriatic arthritis. Multivariate relative risk model |journal=Arthritis Rheum. |volume=38 |issue=6 |pages=845–50 |year=1995 |month=June |pmid=7779129 |doi= |url=] was observed in several studies. Psoriatic arthritis appears to be linked to MICA-A9 which tightly linked to HLA-B39.cite journal |author=Bolognesi E, Dalfonso S, Rolando V, Fasano ME, Praticò L, Momigliano-Richiardi P |title=MICA and MICB microsatellite alleles in HLA extended haplotypes |journal=Eur. J. Immunogenet. |volume=28 |issue=5 |pages=523–30 |year=2001 |month=October |pmid=11881819 |doi= |url=http://www.blackwell-synergy.com/openurl?genre=article&sid=nlm:pubmed&issn=0960-7420&date=2001&volume=28&issue=5&spage=523] cite journal |author=González S, Martínez-Borra J, López-Vázquez A, García-Fernández S, Torre-Alonso JC, López-Larrea C |title=MICA rather than MICB, TNFA, or HLA-DRB1 is associated with susceptibility to psoriatic arthritis |journal=J. Rheumatol. |volume=29 |issue=5 |pages=973–8 |year=2002 |month=May |pmid=12022360 |doi= |url=http://www.jrheum.com/subscribers/02/05/973.html] B39 also appears to be involved in the Fishers syndrome variant of Guillain-Barré syndrome.cite journal |author=Yuki N, Sato S, Tsuji S, Ogawa K, Miyatake T |title=Human leukocyte antigens in Fisher's syndrome |journal=Ann. Neurol. |volume=33 |issue=6 |pages=655–7 |year=1993 |month=June |pmid=8498847 |doi=10.1002/ana.410330617 |url=]

B39 appears to be protective against cardiomyopathy in Chaga's disease indicating a possible selective factor in its rise in the New World.cite journal |author=Cruz-Robles D, Reyes PA, Monteón-Padilla VM, Ortiz-Muñiz AR, Vargas-Alarcón G |title=MHC class I and class II genes in Mexican patients with Chagas disease |journal=Hum. Immunol. |volume=65 |issue=1 |pages=60–5 |year=2004 |month=January |pmid=14700597 |doi= |url=http://linkinghub.elsevier.com/retrieve/pii/S0198885903006360] Chaga's disease is caused by a trypanosome carried by a blood sucking insect found in tropical, palm growing regions.

In Takayasu's arteritis

Takayasu's arteritis appears to have a link to B39.cite journal |author=Kimura A, Kitamura H, Date Y, Numano F |title=Comprehensive analysis of HLA genes in Takayasu arteritis in Japan |journal=Int. J. Cardiol. |volume=54 Suppl |issue= |pages=S61–9 |year=1996 |month=August |pmid=9119528 |doi= |url=] cite journal |author=Yoshida M, Kimura A, Katsuragi K, Numano F, Sasazuki T |title=DNA typing of HLA-B gene in Takayasu's arteritis |journal=Tissue Antigens |volume=42 |issue=2 |pages=87–90 |year=1993 |month=August |pmid=7903491 |doi= |url=] The association with B*3902 increases risk of pulmonary infarction, ischemic heart disease, aortic regurgitation, systemic hypertension, renal artery stenosis, cerebrovascular disease, and visual disturbance.cite journal |author=Kitamura H, Kobayashi Y, Kimura A, Numano F |title=Association of clinical manifestations with HLA-B alleles in Takayasu arteritis |journal=Int. J. Cardiol. |volume=66 Suppl 1 |issue= |pages=S121–6 |year=1998 |month=October |pmid=9951811 |doi= |url=] B*3906, common in indigenous Mesoamericans has been found associated with the same disease.cite journal |author=Rodríguez-Reyna TS, Zúñiga-Ramos J, Salgado N, "et al" |title=Intron 2 and exon 3 sequences may be involved in the susceptibility to develop Takayasu arteritis |journal=Int. J. Cardiol. |volume=66 Suppl 1 |issue= |pages=S135–8; discussion S139 |year=1998 |month=October |pmid=9951813 |doi= |url=]

References